tetano
Editor, Senior Moderator
Intern Med
. 2022 Apr 9.
doi: 10.2169/internalmedicine.9199-21. Online ahead of print.
Successful Treatment of Immune Thrombocytopenic Purpura with Intracranial Hemorrhaging and Duodenal Bleeding Following SARS-CoV-2 Vaccination
Yuta Baba[SUP] 1 [/SUP], Hirotaka Sakai[SUP] 1 [/SUP], Nobuyuki Kabasawa[SUP] 1 [/SUP], Hiroshi Harada[SUP] 1 [/SUP]
Affiliations
Abstract
Several vaccines have been developed for coronavirus disease 2019-caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-in record time. A few cases of immune thrombocytopenic purpura (ITP) following SARS-CoV-2 vaccination have been reported. We herein report a 90-year-old man who received the Pfizer-BioNTech SARS-CoV-2 vaccine (BNT162b2) and developed severe thrombocytopenia with intracranial hemorrhaging and duodenal bleeding, consistent with vaccine-related ITP. He was successfully treated with intravenous immunoglobulin, prednisolone, and eltrombopag and discharged without cytopenia. Vaccine-related ITP should be suspected in patients presenting with abnormal bleeding or purpura after vaccination.
Keywords: SARS-CoV-2 vaccine; bleeding; immune thrombocytopenic purpura.
Yuta Baba[SUP] 1 [/SUP], Hirotaka Sakai[SUP] 1 [/SUP], Nobuyuki Kabasawa[SUP] 1 [/SUP], Hiroshi Harada[SUP] 1 [/SUP]
Affiliations
Abstract
Several vaccines have been developed for coronavirus disease 2019-caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-in record time. A few cases of immune thrombocytopenic purpura (ITP) following SARS-CoV-2 vaccination have been reported. We herein report a 90-year-old man who received the Pfizer-BioNTech SARS-CoV-2 vaccine (BNT162b2) and developed severe thrombocytopenia with intracranial hemorrhaging and duodenal bleeding, consistent with vaccine-related ITP. He was successfully treated with intravenous immunoglobulin, prednisolone, and eltrombopag and discharged without cytopenia. Vaccine-related ITP should be suspected in patients presenting with abnormal bleeding or purpura after vaccination.
Keywords: SARS-CoV-2 vaccine; bleeding; immune thrombocytopenic purpura.
. 2022 Apr 9.
doi: 10.2169/internalmedicine.9199-21. Online ahead of print.
Successful Treatment of Immune Thrombocytopenic Purpura with Intracranial Hemorrhaging and Duodenal Bleeding Following SARS-CoV-2 Vaccination
Yuta Baba[SUP] 1 [/SUP], Hirotaka Sakai[SUP] 1 [/SUP], Nobuyuki Kabasawa[SUP] 1 [/SUP], Hiroshi Harada[SUP] 1 [/SUP]
Affiliations
- PMID: 35400701
- DOI: 10.2169/internalmedicine.9199-21
Abstract
Several vaccines have been developed for coronavirus disease 2019-caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-in record time. A few cases of immune thrombocytopenic purpura (ITP) following SARS-CoV-2 vaccination have been reported. We herein report a 90-year-old man who received the Pfizer-BioNTech SARS-CoV-2 vaccine (BNT162b2) and developed severe thrombocytopenia with intracranial hemorrhaging and duodenal bleeding, consistent with vaccine-related ITP. He was successfully treated with intravenous immunoglobulin, prednisolone, and eltrombopag and discharged without cytopenia. Vaccine-related ITP should be suspected in patients presenting with abnormal bleeding or purpura after vaccination.
Keywords: SARS-CoV-2 vaccine; bleeding; immune thrombocytopenic purpura.
Yuta Baba[SUP] 1 [/SUP], Hirotaka Sakai[SUP] 1 [/SUP], Nobuyuki Kabasawa[SUP] 1 [/SUP], Hiroshi Harada[SUP] 1 [/SUP]
Affiliations
- PMID: 35400701
- DOI: 10.2169/internalmedicine.9199-21
Abstract
Several vaccines have been developed for coronavirus disease 2019-caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-in record time. A few cases of immune thrombocytopenic purpura (ITP) following SARS-CoV-2 vaccination have been reported. We herein report a 90-year-old man who received the Pfizer-BioNTech SARS-CoV-2 vaccine (BNT162b2) and developed severe thrombocytopenia with intracranial hemorrhaging and duodenal bleeding, consistent with vaccine-related ITP. He was successfully treated with intravenous immunoglobulin, prednisolone, and eltrombopag and discharged without cytopenia. Vaccine-related ITP should be suspected in patients presenting with abnormal bleeding or purpura after vaccination.
Keywords: SARS-CoV-2 vaccine; bleeding; immune thrombocytopenic purpura.