tetano
Editor, Senior Moderator
Intern Med
. 2022;61(14):2215-2219.
doi: 10.2169/internalmedicine.9513-22. Epub 2022 Jul 15.
Successful Elimination of SARS-CoV-2 Following Vaccination with BNT162b2 after Prolonged Viral Infection in an Immunocompromised Lymphoma Patient
Masao Hagihara[SUP] 1 [/SUP], Yui Imai[SUP] 1 [/SUP], Tomoyuki Uchida[SUP] 1 [/SUP], Shin Ohara[SUP] 1 [/SUP], Morihiro Inoue[SUP] 1 [/SUP], Tomiyuki Sugi[SUP] 2 [/SUP], Keiko Mitamura[SUP] 3 [/SUP]
Affiliations
Abstract
A 52-year-old man with mantle cell lymphoma treated with bendamustine and rituximab developed prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Despite elevated titers of anti-spike IgG antibody, protracted pancytopenia persisted for more than six months. Finally, the anti-SARS CoV-2 vaccine, BNT162b2, was administered, which improved his blood cell count and eliminated the virus. The increased anti-spike IgG titer and lymphocyte count after vaccination suggested that both humoral and cellular immunity acted in coordination to eliminate the virus.
Keywords: SARS-CoV-2; anti-spike IgG; bendamustine; cellular immunity; prolonged infection; vaccine.
. 2022;61(14):2215-2219.
doi: 10.2169/internalmedicine.9513-22. Epub 2022 Jul 15.
Successful Elimination of SARS-CoV-2 Following Vaccination with BNT162b2 after Prolonged Viral Infection in an Immunocompromised Lymphoma Patient
Masao Hagihara[SUP] 1 [/SUP], Yui Imai[SUP] 1 [/SUP], Tomoyuki Uchida[SUP] 1 [/SUP], Shin Ohara[SUP] 1 [/SUP], Morihiro Inoue[SUP] 1 [/SUP], Tomiyuki Sugi[SUP] 2 [/SUP], Keiko Mitamura[SUP] 3 [/SUP]
Affiliations
- PMID: 35850990
- DOI: 10.2169/internalmedicine.9513-22
Abstract
A 52-year-old man with mantle cell lymphoma treated with bendamustine and rituximab developed prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Despite elevated titers of anti-spike IgG antibody, protracted pancytopenia persisted for more than six months. Finally, the anti-SARS CoV-2 vaccine, BNT162b2, was administered, which improved his blood cell count and eliminated the virus. The increased anti-spike IgG titer and lymphocyte count after vaccination suggested that both humoral and cellular immunity acted in coordination to eliminate the virus.
Keywords: SARS-CoV-2; anti-spike IgG; bendamustine; cellular immunity; prolonged infection; vaccine.