tetano
Editor, Senior Moderator
Intern Med
. 2022 Dec 28.
doi: 10.2169/internalmedicine.0504-22. Online ahead of print.
Relapsing Anti-MOG Antibody-associated Disease Following COVID-19 Vaccination: A Rare Case Report and Review of the Literature
Hiroto Nakano[SUP] 1 [/SUP], Kazuyoshi Yamaguchi[SUP] 1 [/SUP], Naoyuki Hama[SUP] 1 [/SUP], Yasuko Matsumoto[SUP] 1 [/SUP], Moeko Shinohara[SUP] 2 [/SUP], Hisashi Ide[SUP] 3 [/SUP]
Affiliations
Abstract
Anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune demyelinating disorder that mainly occurs post-infection or post-vaccination. MOGAD after inoculation with coronavirus disease 2019 (COVID-19) vaccines is rare, and we herein report a rare case of a patient with MOGAD after vaccination using the Pfizer-BioNTech COVID-19 vaccine (BNT162b2; Pfizer Japan Inc.; Tokyo). Our report highlights the fact that MOGAD following inoculation with COVID-19 vaccine may show clinical relapse during reduction of the oral steroid dose, and continuous treatments with immunological agents is needed to prevent disease recurrence.
Keywords: MOG; SARS-CoV-2; anti-MOG antibody-associated disease; steroid; vaccination.
. 2022 Dec 28.
doi: 10.2169/internalmedicine.0504-22. Online ahead of print.
Relapsing Anti-MOG Antibody-associated Disease Following COVID-19 Vaccination: A Rare Case Report and Review of the Literature
Hiroto Nakano[SUP] 1 [/SUP], Kazuyoshi Yamaguchi[SUP] 1 [/SUP], Naoyuki Hama[SUP] 1 [/SUP], Yasuko Matsumoto[SUP] 1 [/SUP], Moeko Shinohara[SUP] 2 [/SUP], Hisashi Ide[SUP] 3 [/SUP]
Affiliations
- PMID: 36575011
- DOI: 10.2169/internalmedicine.0504-22
Abstract
Anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune demyelinating disorder that mainly occurs post-infection or post-vaccination. MOGAD after inoculation with coronavirus disease 2019 (COVID-19) vaccines is rare, and we herein report a rare case of a patient with MOGAD after vaccination using the Pfizer-BioNTech COVID-19 vaccine (BNT162b2; Pfizer Japan Inc.; Tokyo). Our report highlights the fact that MOGAD following inoculation with COVID-19 vaccine may show clinical relapse during reduction of the oral steroid dose, and continuous treatments with immunological agents is needed to prevent disease recurrence.
Keywords: MOG; SARS-CoV-2; anti-MOG antibody-associated disease; steroid; vaccination.