tetano
Editor, Senior Moderator
Intern Med
. 2025 Dec 11.
doi: 10.2169/internalmedicine.5163-24. Online ahead of print. New-onset anti-melanoma differentiation-associated gene 5 antibody positive clinically amyopathic dermatomyositis following COVID-19: A case report
Yu Nakanishi[SUP] 1 2 [/SUP], Hirofumi Watanabe[SUP] 3 [/SUP], Mako Tsuyuki[SUP] 1 [/SUP], Shinji Kakumoto[SUP] 1 [/SUP], Masaaki Abe[SUP] 1 [/SUP], Kosuke Hamai[SUP] 1 [/SUP]
Affiliations
Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, is a life-threatening respiratory illness that shares clinical similarities with autoimmune diseases, which some patients subsequently develop. We herein report a case of an older Japanese patient who presented with skin rash, relapsing progressive interstitial lung disease, and anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody seropositivity after COVID-19 infection. Although the patient was elderly, her symptoms improved with the administration of corticosteroids, tacrolimus, and intravenous cyclophosphamide, indicating that this combination may be a viable treatment option for anti-MDA5 antibody-positive pneumonia, which is a complication of COVID-19.
Keywords: amyopathic dermatomyositis; anti-melanoma differentiation-associated gene 5 antibody; autoimmune diseases; coronavirus disease 2019; intravenous cyclophosphamide.
. 2025 Dec 11.
doi: 10.2169/internalmedicine.5163-24. Online ahead of print. New-onset anti-melanoma differentiation-associated gene 5 antibody positive clinically amyopathic dermatomyositis following COVID-19: A case report
Yu Nakanishi[SUP] 1 2 [/SUP], Hirofumi Watanabe[SUP] 3 [/SUP], Mako Tsuyuki[SUP] 1 [/SUP], Shinji Kakumoto[SUP] 1 [/SUP], Masaaki Abe[SUP] 1 [/SUP], Kosuke Hamai[SUP] 1 [/SUP]
Affiliations
- PMID: 41371642
- DOI: 10.2169/internalmedicine.5163-24
Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, is a life-threatening respiratory illness that shares clinical similarities with autoimmune diseases, which some patients subsequently develop. We herein report a case of an older Japanese patient who presented with skin rash, relapsing progressive interstitial lung disease, and anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody seropositivity after COVID-19 infection. Although the patient was elderly, her symptoms improved with the administration of corticosteroids, tacrolimus, and intravenous cyclophosphamide, indicating that this combination may be a viable treatment option for anti-MDA5 antibody-positive pneumonia, which is a complication of COVID-19.
Keywords: amyopathic dermatomyositis; anti-melanoma differentiation-associated gene 5 antibody; autoimmune diseases; coronavirus disease 2019; intravenous cyclophosphamide.