tetano
Editor, Senior Moderator
Intern Med
. 2022 May 31.
doi: 10.2169/internalmedicine.9800-22. Online ahead of print.
Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination: A Case Report
Hiroaki Kawano[SUP] 1 [/SUP], Tetsufumi Motokawa[SUP] 1 [/SUP], Hirokazu Kurohama[SUP] 2 [/SUP], Shinji Okano[SUP] 2 [/SUP], Ryohei Akashi[SUP] 1 [/SUP], Tsuyoshi Yonekura[SUP] 1 [/SUP], Satoshi Ikeda[SUP] 1 [/SUP], Koichi Izumikawa[SUP] 3 [/SUP], Koji Maemura[SUP] 1 [/SUP]
Affiliations
Abstract
A 60-year-old Japanese woman was hospitalized for cardiogenic shock 24 days after receiving the second dose of the COVID-19 BNT162b2 vaccine. Impella-CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were immediately initiated along with inotropic support and steroid pulse therapy, as an endomyocardial biopsy specimen showed myocarditis. Three weeks later, her cardiac function had recovered, and she was discharged. An immune response associated with the presence of spike protein in cardiac myocytes may be related to myocarditis in the present case because of positive immunostaining for severe acute respiratory syndrome coronavirus 2 spike protein and C4d in the myocardium.
Keywords: biopsy; inflammation; pathology.
. 2022 May 31.
doi: 10.2169/internalmedicine.9800-22. Online ahead of print.
Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination: A Case Report
Hiroaki Kawano[SUP] 1 [/SUP], Tetsufumi Motokawa[SUP] 1 [/SUP], Hirokazu Kurohama[SUP] 2 [/SUP], Shinji Okano[SUP] 2 [/SUP], Ryohei Akashi[SUP] 1 [/SUP], Tsuyoshi Yonekura[SUP] 1 [/SUP], Satoshi Ikeda[SUP] 1 [/SUP], Koichi Izumikawa[SUP] 3 [/SUP], Koji Maemura[SUP] 1 [/SUP]
Affiliations
- PMID: 35650138
- DOI: 10.2169/internalmedicine.9800-22
Abstract
A 60-year-old Japanese woman was hospitalized for cardiogenic shock 24 days after receiving the second dose of the COVID-19 BNT162b2 vaccine. Impella-CP left ventricular assist device implantation and venoarterial peripheral extracorporeal membranous oxygenation were immediately initiated along with inotropic support and steroid pulse therapy, as an endomyocardial biopsy specimen showed myocarditis. Three weeks later, her cardiac function had recovered, and she was discharged. An immune response associated with the presence of spike protein in cardiac myocytes may be related to myocarditis in the present case because of positive immunostaining for severe acute respiratory syndrome coronavirus 2 spike protein and C4d in the myocardium.
Keywords: biopsy; inflammation; pathology.