tetano
Editor, Senior Moderator
Intern Med
. 2023;62(12):1765-1770.
doi: 10.2169/internalmedicine.1421-22. Epub 2023 Jun 15. Combined REGN-COV2 Antibody Therapy Immediately Prevented a Patient with Refractory Type 1 Autoimmune Pancreatitis from Contracting SARS-CoV-2 during the Sixth Wave in Japan
Chihiro Katsuso[SUP] 1 [/SUP], Kensuke Kubota[SUP] 1 [/SUP], Katsushi Tanaka[SUP] 2 [/SUP], Yusuke Kurita[SUP] 1 [/SUP], Atsushi Nakajima[SUP] 1 [/SUP]
Affiliations
A 51-year-old man who had been receiving steroid therapy for type 1 autoimmune pancreatitis (AIP) for 3 years contracted coronavirus disease 2019 (COVID-19). As he had a high-grade fever and dry cough, and because his SpO[SUB]2[/SUB] level had dropped below 95% in the supine position, he was considered as being at a high risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); therefore, he received combined REGN-COV2 antibody therapy. The patient's fever resolved immediately after this treatment, and he went into remission. A high cumulative steroid dose is associated with an increased susceptibility to infection. Early antibody cocktail therapy may be effective and rewarding for steroid-dependent type 1 AIP patients with a potential risk for SARS-CoV-2.
Keywords: COVID19; REGN-COV2 antibody combination therapy; autoimmune pancreatitis.
. 2023;62(12):1765-1770.
doi: 10.2169/internalmedicine.1421-22. Epub 2023 Jun 15. Combined REGN-COV2 Antibody Therapy Immediately Prevented a Patient with Refractory Type 1 Autoimmune Pancreatitis from Contracting SARS-CoV-2 during the Sixth Wave in Japan
Chihiro Katsuso[SUP] 1 [/SUP], Kensuke Kubota[SUP] 1 [/SUP], Katsushi Tanaka[SUP] 2 [/SUP], Yusuke Kurita[SUP] 1 [/SUP], Atsushi Nakajima[SUP] 1 [/SUP]
Affiliations
- PMID: 37316279
- DOI: 10.2169/internalmedicine.1421-22
A 51-year-old man who had been receiving steroid therapy for type 1 autoimmune pancreatitis (AIP) for 3 years contracted coronavirus disease 2019 (COVID-19). As he had a high-grade fever and dry cough, and because his SpO[SUB]2[/SUB] level had dropped below 95% in the supine position, he was considered as being at a high risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); therefore, he received combined REGN-COV2 antibody therapy. The patient's fever resolved immediately after this treatment, and he went into remission. A high cumulative steroid dose is associated with an increased susceptibility to infection. Early antibody cocktail therapy may be effective and rewarding for steroid-dependent type 1 AIP patients with a potential risk for SARS-CoV-2.
Keywords: COVID19; REGN-COV2 antibody combination therapy; autoimmune pancreatitis.