tetano
Editor, Senior Moderator
Intern Med
. 2023 Sep 22.
doi: 10.2169/internalmedicine.2471-23. Online ahead of print. Association of Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease with Coronavirus Disease 2019 Vaccination and Infection: A Case Report of Cortical Encephalitis and Transverse Myelitis Relapse
Yohei Himeno[SUP] 1 [/SUP], Takahisa Tateishi[SUP] 1 [/SUP], Ken-Ichi Irie[SUP] 1 [/SUP], Shuntaro Ueno[SUP] 1 [/SUP], Makoto Morimitsu[SUP] 1 [/SUP], Shino Mizoguchi[SUP] 1 [/SUP], Tamon Koga[SUP] 1 [/SUP], Takayuki Taniwaki[SUP] 1 [/SUP]
Affiliations
We herein report a case of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) that occurred following coronavirus disease 2019 (COVID-19) vaccination and its subsequent relapse after COVID-19 infection. A 34-year-old woman developed cortical encephalitis in the right temporoparietal lobe one week after receiving the mRNA-1273 vaccine. The cerebrospinal fluid was positive for anti-MOG antibody. Her symptoms gradually improved after three courses of intravenous methylprednisolone therapy. Six months later, she experienced a relapse of transverse myelitis following COVID-19 infection. Despite treatment with plasma exchange, the patient remained paralyzed in both lower limbs. We herein review the relationship between MOGAD and COVID-19 vaccination/infection.
Keywords: Anti MOG antibody; COVID-19 infection; COVID-19 vaccination; Cortical encephalitis; MOG antibody associated disorder; Transverse myelitis.
. 2023 Sep 22.
doi: 10.2169/internalmedicine.2471-23. Online ahead of print. Association of Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease with Coronavirus Disease 2019 Vaccination and Infection: A Case Report of Cortical Encephalitis and Transverse Myelitis Relapse
Yohei Himeno[SUP] 1 [/SUP], Takahisa Tateishi[SUP] 1 [/SUP], Ken-Ichi Irie[SUP] 1 [/SUP], Shuntaro Ueno[SUP] 1 [/SUP], Makoto Morimitsu[SUP] 1 [/SUP], Shino Mizoguchi[SUP] 1 [/SUP], Tamon Koga[SUP] 1 [/SUP], Takayuki Taniwaki[SUP] 1 [/SUP]
Affiliations
- PMID: 37743511
- DOI: 10.2169/internalmedicine.2471-23
We herein report a case of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) that occurred following coronavirus disease 2019 (COVID-19) vaccination and its subsequent relapse after COVID-19 infection. A 34-year-old woman developed cortical encephalitis in the right temporoparietal lobe one week after receiving the mRNA-1273 vaccine. The cerebrospinal fluid was positive for anti-MOG antibody. Her symptoms gradually improved after three courses of intravenous methylprednisolone therapy. Six months later, she experienced a relapse of transverse myelitis following COVID-19 infection. Despite treatment with plasma exchange, the patient remained paralyzed in both lower limbs. We herein review the relationship between MOGAD and COVID-19 vaccination/infection.
Keywords: Anti MOG antibody; COVID-19 infection; COVID-19 vaccination; Cortical encephalitis; MOG antibody associated disorder; Transverse myelitis.