tetano
Editor, Senior Moderator
Intern Med
. 2022 Sep 13.
doi: 10.2169/internalmedicine.0404-22. Online ahead of print.
Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination
Masanobu Tanemoto[SUP] 1 [/SUP], Ryosuke Oda[SUP] 2 [/SUP], Yuichiro Toyama[SUP] 2 [/SUP], Hirohiko Shizukawa[SUP] 2 [/SUP], Kazuki Yokokawa[SUP] 1 [/SUP], Taro Saito[SUP] 1 [/SUP], Syuuichirou Suzuki[SUP] 1 [/SUP], Akihiro Matsumura[SUP] 1 [/SUP], Shin Hisahara[SUP] 1 [/SUP]
Affiliations
Abstract
A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably.
Keywords: SARS-CoV-2; anti-signal recognition particle antibody; immune-mediated necrotizing myopathy; myopathy; vaccine.
. 2022 Sep 13.
doi: 10.2169/internalmedicine.0404-22. Online ahead of print.
Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination
Masanobu Tanemoto[SUP] 1 [/SUP], Ryosuke Oda[SUP] 2 [/SUP], Yuichiro Toyama[SUP] 2 [/SUP], Hirohiko Shizukawa[SUP] 2 [/SUP], Kazuki Yokokawa[SUP] 1 [/SUP], Taro Saito[SUP] 1 [/SUP], Syuuichirou Suzuki[SUP] 1 [/SUP], Akihiro Matsumura[SUP] 1 [/SUP], Shin Hisahara[SUP] 1 [/SUP]
Affiliations
- PMID: 36104199
- DOI: 10.2169/internalmedicine.0404-22
Abstract
A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably.
Keywords: SARS-CoV-2; anti-signal recognition particle antibody; immune-mediated necrotizing myopathy; myopathy; vaccine.