tetano
Editor, Senior Moderator
Intern Med
. 2025 Feb 8.
doi: 10.2169/internalmedicine.4741-24. Online ahead of print. A Case of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Caused by Influenza A Infection
Satomi Okano[SUP] 1 [/SUP], Akio Kimura[SUP] 2 [/SUP], Takashi Ogasawara[SUP] 1 [/SUP], Koji Tagawa[SUP] 1 [/SUP], Miho Oshima[SUP] 1 [/SUP], Mitsuo Narita[SUP] 1 [/SUP], Toshiaki Oka[SUP] 1 [/SUP], Tomoaki Murakami[SUP] 1 [/SUP], Makoto Kaneda[SUP] 1 [/SUP]
Affiliations
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a new spectrum of autoimmune inflammatory nervous system disorders associated with infection, neoplasm, or drug use. We present the first pediatric case of GFAP astrocytopathy caused by an influenza A infection. The patient manifested meningoencephalitis, central respiratory failure, quadriplegia, elimination disorders, and syndrome of inappropriate antidiuretic hormone secretion. Methylprednisolone pulse therapy led to a good prognosis. In cases of progressive atypical complications of influenza infection, immunotherapy-reactive GFAP astrocytopathy should be considered as a differential diagnosis for prompt treatment.
Keywords: glial fibrillary acidic protein; influenza A virus; meningoencephalitis; methylprednisolone; quadriplegia; respiratory failure.
. 2025 Feb 8.
doi: 10.2169/internalmedicine.4741-24. Online ahead of print. A Case of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Caused by Influenza A Infection
Satomi Okano[SUP] 1 [/SUP], Akio Kimura[SUP] 2 [/SUP], Takashi Ogasawara[SUP] 1 [/SUP], Koji Tagawa[SUP] 1 [/SUP], Miho Oshima[SUP] 1 [/SUP], Mitsuo Narita[SUP] 1 [/SUP], Toshiaki Oka[SUP] 1 [/SUP], Tomoaki Murakami[SUP] 1 [/SUP], Makoto Kaneda[SUP] 1 [/SUP]
Affiliations
- PMID: 39924240
- DOI: 10.2169/internalmedicine.4741-24
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a new spectrum of autoimmune inflammatory nervous system disorders associated with infection, neoplasm, or drug use. We present the first pediatric case of GFAP astrocytopathy caused by an influenza A infection. The patient manifested meningoencephalitis, central respiratory failure, quadriplegia, elimination disorders, and syndrome of inappropriate antidiuretic hormone secretion. Methylprednisolone pulse therapy led to a good prognosis. In cases of progressive atypical complications of influenza infection, immunotherapy-reactive GFAP astrocytopathy should be considered as a differential diagnosis for prompt treatment.
Keywords: glial fibrillary acidic protein; influenza A virus; meningoencephalitis; methylprednisolone; quadriplegia; respiratory failure.