tetano
Editor, Senior Moderator
Rev Esp Quimioter. 2018 Nov 5. pii: ramos5nov2018. [Epub ahead of print]
[h=1]Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu.[/h] Ramos JM[SUP]1[/SUP], Garc?a-Navarro M, Moreno V, Gonz?lez-de-la-Aleja P, Gimeno-Gasc?n A, Merino E, Portilla J.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] The role of tumor necrosis factor (TNF), interleukin (IL)-1β and IL-6 in the pathogenicity of seasonal flu is unknown.
[h=4]METHODS:[/h] We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (real-time polymerase chain reaction).
[h=4]RESULTS:[/h] Flu patients had lower monocyte counts (p=0.029) and a slightly lower median level of IL-6 (P=0.05) than the control group. Twenty-four flu patients (31.2%) had pneumonia; this group had higher C-reactive proteins (p=0.01) and monocyte levels (p=0.009). Pro-inflammatory cytokines levels did not rise in patients with pneumonia complicating seasonal influenza.
[h=4]CONCLUSIONS:[/h] IL-6 levels were lower in adults with influenza.
?The Author 2018. Published by Sociedad Espa?ola de Quimioterapia. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/).
PMID: 30421883
[h=1]Interleukin (IL) -1 β, IL-6 and tumor necrosis factor in patients with seasonal flu.[/h] Ramos JM[SUP]1[/SUP], Garc?a-Navarro M, Moreno V, Gonz?lez-de-la-Aleja P, Gimeno-Gasc?n A, Merino E, Portilla J.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] The role of tumor necrosis factor (TNF), interleukin (IL)-1β and IL-6 in the pathogenicity of seasonal flu is unknown.
[h=4]METHODS:[/h] We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (real-time polymerase chain reaction).
[h=4]RESULTS:[/h] Flu patients had lower monocyte counts (p=0.029) and a slightly lower median level of IL-6 (P=0.05) than the control group. Twenty-four flu patients (31.2%) had pneumonia; this group had higher C-reactive proteins (p=0.01) and monocyte levels (p=0.009). Pro-inflammatory cytokines levels did not rise in patients with pneumonia complicating seasonal influenza.
[h=4]CONCLUSIONS:[/h] IL-6 levels were lower in adults with influenza.
?The Author 2018. Published by Sociedad Espa?ola de Quimioterapia. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/).
PMID: 30421883