tetano
Editor, Senior Moderator
Immunol Rev. 2013 Sep;255(1):25-39. doi: 10.1111/imr.12101.
Interferon induction and function at the mucosal surface.
Durbin RK, Kotenko SV, Durbin JE.
Source
Department of Pathology, New York University School of Medicine, New York, NY, USA.
Abstract
Interferons (IFNs) are produced in response to virus infection and induce an antiviral state in virtually all cell types. In addition to upregulating the transcription of genes that inhibit virus replication, type I (or -α/β) IFNs also act to orchestrate the adaptive immune response to virus infection. Recently a new family of antiviral cytokines, the type III (or -λ) IFNs, has been identified that activate the same antiviral pathways via a distinct receptor. Although the identical transcription factor, IFN-stimulated gene factor 3 is activated by either IFN-α/β or IFN-λ signaling, differences in the induction and action of these two cytokine families are beginning to be appreciated. In this article, we review this emerging body of literature on the differing roles these cytokines play in host defense of the mucosal surface. Although many viruses enter the body through the respiratory and gastrointestinal tracts, we have focused the discussion on influenza A virus, respiratory syncytial virus, and rotavirus, three ubiquitous human pathogens that target the epithelial lining and are associated with a major disease burden.
? 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
KEYWORDS:
IFN induction, Stat signaling, influenza A virus, interferon, respiratory syncytial virus, rotavirus
PMID:
23947345
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23947345
Interferon induction and function at the mucosal surface.
Durbin RK, Kotenko SV, Durbin JE.
Source
Department of Pathology, New York University School of Medicine, New York, NY, USA.
Abstract
Interferons (IFNs) are produced in response to virus infection and induce an antiviral state in virtually all cell types. In addition to upregulating the transcription of genes that inhibit virus replication, type I (or -α/β) IFNs also act to orchestrate the adaptive immune response to virus infection. Recently a new family of antiviral cytokines, the type III (or -λ) IFNs, has been identified that activate the same antiviral pathways via a distinct receptor. Although the identical transcription factor, IFN-stimulated gene factor 3 is activated by either IFN-α/β or IFN-λ signaling, differences in the induction and action of these two cytokine families are beginning to be appreciated. In this article, we review this emerging body of literature on the differing roles these cytokines play in host defense of the mucosal surface. Although many viruses enter the body through the respiratory and gastrointestinal tracts, we have focused the discussion on influenza A virus, respiratory syncytial virus, and rotavirus, three ubiquitous human pathogens that target the epithelial lining and are associated with a major disease burden.
? 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
KEYWORDS:
IFN induction, Stat signaling, influenza A virus, interferon, respiratory syncytial virus, rotavirus
PMID:
23947345
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23947345