tetano
Editor, Senior Moderator
Interface Focus
. 2021 Dec 10;12(1):20210006.
doi: 10.1098/rsfs.2021.0006. eCollection 2022 Feb 6.
Potential therapeutic approaches for targeted inhibition of inflammatory cytokines following COVID-19 infection-induced cytokine storm
Nelli Morgulchik[SUP] 1 [/SUP], Foteini Athanasopoulou[SUP] 1 [/SUP], Edmund Chu[SUP] 1 [/SUP], Yoriko Lam[SUP] 1 [/SUP], Nazila Kamaly[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a deadly respiratory disease caused by severe acute respiratory syndrome coronavirus 2, which has caused a global pandemic since early 2020 and severely threatened people's livelihoods and health. Patients with pre-diagnosed conditions admitted to hospital often develop complications leading to mortality due to acute respiratory distress syndrome (ARDS) and associated multiorgan failure and blood clots. ARDS is associated with a cytokine storm. Cytokine storms arise due to elevated levels of circulating cytokines and are associated with infections. Targeting various pro-inflammatory cytokines in a specific manner can result in a potent therapeutic approach with minimal host collateral damage. Immunoregulatory therapies are now of interest in order to regulate the cytokine storm, and this review will summarize and discuss advances in targeted therapies against cytokine storms induced by COVID-19.
Keywords: COVID-19; anti-inflammatory; biologics; cytokine storm; multiorgan failure; targeted therapy.
. 2021 Dec 10;12(1):20210006.
doi: 10.1098/rsfs.2021.0006. eCollection 2022 Feb 6.
Potential therapeutic approaches for targeted inhibition of inflammatory cytokines following COVID-19 infection-induced cytokine storm
Nelli Morgulchik[SUP] 1 [/SUP], Foteini Athanasopoulou[SUP] 1 [/SUP], Edmund Chu[SUP] 1 [/SUP], Yoriko Lam[SUP] 1 [/SUP], Nazila Kamaly[SUP] 1 [/SUP]
Affiliations
- PMID: 34956607
- PMCID: PMC8662389
- DOI: 10.1098/rsfs.2021.0006
Abstract
Coronavirus disease 2019 (COVID-19) is a deadly respiratory disease caused by severe acute respiratory syndrome coronavirus 2, which has caused a global pandemic since early 2020 and severely threatened people's livelihoods and health. Patients with pre-diagnosed conditions admitted to hospital often develop complications leading to mortality due to acute respiratory distress syndrome (ARDS) and associated multiorgan failure and blood clots. ARDS is associated with a cytokine storm. Cytokine storms arise due to elevated levels of circulating cytokines and are associated with infections. Targeting various pro-inflammatory cytokines in a specific manner can result in a potent therapeutic approach with minimal host collateral damage. Immunoregulatory therapies are now of interest in order to regulate the cytokine storm, and this review will summarize and discuss advances in targeted therapies against cytokine storms induced by COVID-19.
Keywords: COVID-19; anti-inflammatory; biologics; cytokine storm; multiorgan failure; targeted therapy.
