tetano
Editor, Senior Moderator
J Interferon Cytokine Res. 2017 May 17. doi: 10.1089/jir.2017.0032. [Epub ahead of print]
[h=1]Interactions Between NS1 of Influenza A Viruses and Interferon-α/β: Determinants for Vaccine Development.[/h] Wang BX[SUP]1,[/SUP][SUP]2[/SUP], Fish EN[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A viruses (IAVs) cause mild to severe infections in humans with considerable socioeconomic and global health consequences. The host interferon (IFN)-α/β response, critical as the first line of defense against foreign pathogens, is induced upon detection of IAV genomic RNA in infected cells by host innate pattern recognition receptors. IFN-α/β production and subsequent activation of cell signaling result in the expression of antiviral IFN-stimulated genes whose products target various stages of the IAV life cycle to inhibit viral replication and the spread of infection and establish an antiviral state. IAVs, however, encode a multifunctional virulence factor, nonstructural protein 1 (NS1), that directly antagonizes the host IFN-α/β response to support viral replication. In this review, we highlight the mechanisms by which NS1 suppresses IFN-α/β production and subsequent cell signaling, and consider, therefore, the potential for recombinant IAVs lacking NS1 to be used as live-attenuated vaccines.
[h=4]KEYWORDS:[/h] IFN-α/β; host?pathogen interactions; influenza A virus; interferon-stimulated genes; nonstructural protein 1
PMID: 28514196 DOI: 10.1089/jir.2017.0032
[h=1]Interactions Between NS1 of Influenza A Viruses and Interferon-α/β: Determinants for Vaccine Development.[/h] Wang BX[SUP]1,[/SUP][SUP]2[/SUP], Fish EN[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A viruses (IAVs) cause mild to severe infections in humans with considerable socioeconomic and global health consequences. The host interferon (IFN)-α/β response, critical as the first line of defense against foreign pathogens, is induced upon detection of IAV genomic RNA in infected cells by host innate pattern recognition receptors. IFN-α/β production and subsequent activation of cell signaling result in the expression of antiviral IFN-stimulated genes whose products target various stages of the IAV life cycle to inhibit viral replication and the spread of infection and establish an antiviral state. IAVs, however, encode a multifunctional virulence factor, nonstructural protein 1 (NS1), that directly antagonizes the host IFN-α/β response to support viral replication. In this review, we highlight the mechanisms by which NS1 suppresses IFN-α/β production and subsequent cell signaling, and consider, therefore, the potential for recombinant IAVs lacking NS1 to be used as live-attenuated vaccines.
[h=4]KEYWORDS:[/h] IFN-α/β; host?pathogen interactions; influenza A virus; interferon-stimulated genes; nonstructural protein 1
PMID: 28514196 DOI: 10.1089/jir.2017.0032