tetano
Editor, Senior Moderator
Intensive Care Med
. 2020 Aug 20.
doi: 10.1007/s00134-020-06211-2. Online ahead of print.
Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study
Jianfeng Xie[SUP] 1 [/SUP], Wenjuan Wu[SUP] 2 [/SUP], Shusheng Li[SUP] 3 [/SUP], Yu Hu[SUP] 4 [/SUP], Ming Hu[SUP] 5 [/SUP], Jinxiu Li[SUP] 6 [/SUP], Yi Yang[SUP] 1 [/SUP], Tingrong Huang[SUP] 7 [/SUP], Kun Zheng[SUP] 8 [/SUP], Yishan Wang[SUP] 9 [/SUP], Hanyujie Kang[SUP] 9 [/SUP], Yingzi Huang[SUP] 1 [/SUP], Li Jiang[SUP] 10 [/SUP], Wei Zhang[SUP] 11 [/SUP], Ming Zhong[SUP] 12 [/SUP], Ling Sang[SUP] 13 [/SUP], Xia Zheng[SUP] 14 [/SUP], Chun Pan[SUP] 1 [/SUP], Ruiqiang Zheng[SUP] 15 [/SUP], Xuyan Li[SUP] 9 [/SUP], Zhaohui Tong[SUP] 16 [/SUP], Haibo Qiu[SUP] 17 [/SUP], Bin Du[SUP] 18 [/SUP]
Affiliations
Abstract
Purpose: An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality.
Methods: We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors.
Results: Of the 733 patients included in the study, the median (IQR) age was 65 (56-73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, high D-dimer level, low PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] level, high creatinine level, high hscTnI level and low albumin level were independent risk factors of 28-day mortality in critically ill patients with COVID-19.
Conclusion: In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources.
Keywords: COVID-19; Critically ill; Mortality; Organ failure.
. 2020 Aug 20.
doi: 10.1007/s00134-020-06211-2. Online ahead of print.
Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study
Jianfeng Xie[SUP] 1 [/SUP], Wenjuan Wu[SUP] 2 [/SUP], Shusheng Li[SUP] 3 [/SUP], Yu Hu[SUP] 4 [/SUP], Ming Hu[SUP] 5 [/SUP], Jinxiu Li[SUP] 6 [/SUP], Yi Yang[SUP] 1 [/SUP], Tingrong Huang[SUP] 7 [/SUP], Kun Zheng[SUP] 8 [/SUP], Yishan Wang[SUP] 9 [/SUP], Hanyujie Kang[SUP] 9 [/SUP], Yingzi Huang[SUP] 1 [/SUP], Li Jiang[SUP] 10 [/SUP], Wei Zhang[SUP] 11 [/SUP], Ming Zhong[SUP] 12 [/SUP], Ling Sang[SUP] 13 [/SUP], Xia Zheng[SUP] 14 [/SUP], Chun Pan[SUP] 1 [/SUP], Ruiqiang Zheng[SUP] 15 [/SUP], Xuyan Li[SUP] 9 [/SUP], Zhaohui Tong[SUP] 16 [/SUP], Haibo Qiu[SUP] 17 [/SUP], Bin Du[SUP] 18 [/SUP]
Affiliations
- PMID: 32816098
- DOI: 10.1007/s00134-020-06211-2
Abstract
Purpose: An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality.
Methods: We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors.
Results: Of the 733 patients included in the study, the median (IQR) age was 65 (56-73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, high D-dimer level, low PaO[SUB]2[/SUB]/FiO[SUB]2[/SUB] level, high creatinine level, high hscTnI level and low albumin level were independent risk factors of 28-day mortality in critically ill patients with COVID-19.
Conclusion: In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources.
Keywords: COVID-19; Critically ill; Mortality; Organ failure.