tetano
Editor, Senior Moderator
J Infect Dis. 2015 Mar 17. pii: jiv177. [Epub ahead of print]
[h=1]Integrated sentinel surveillance linking genetic, antigenic and epidemiologic monitoring of influenza vaccine-virus relatedness and effectiveness, 2013-14 season.[/h] Skowronski DM[SUP]1[/SUP], Chambers C[SUP]2[/SUP], Sabaiduc S[SUP]2[/SUP], De Serres G[SUP]3[/SUP], Winter AL[SUP]4[/SUP], Dickinson JA[SUP]5[/SUP], Gubbay J[SUP]6[/SUP], Fonseca K[SUP]7[/SUP], Charest H[SUP]8[/SUP], Krajden M[SUP]9[/SUP], Petric M[SUP]10[/SUP], Mahmud SM[SUP]11[/SUP], Van Caeseele P[SUP]12[/SUP], Bastien N[SUP]13[/SUP], Eshaghi A[SUP]4[/SUP], Li Y[SUP]14[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Canada's Sentinel Physician Surveillance Network (SPSN) links genetic, antigenic and vaccine effectiveness (VE) measures in an integrated platform of influenza monitoring, described here for the 2013-14 season of resurgent A(H1N1)pdm09 and late-season influenza B activity.
[h=4]METHODS:[/h] VE was estimated as [1-OddsRatio]x100% comparing vaccination status between influenza test-positive cases and test-negative controls. Vaccine-virus relatedness was assessed by genomic sequence analysis and hemagglutination-inhibition assay.
[h=4]RESULTS:[/h] Analyses included 1037 controls (33%vaccinated) and 663 cases (15%vaccinated): 415 A(H1N1)pdm09, 15 A(H3N2), 191 B/Yamagata-lineage, 6 B/Victoria-lineage, 36 unknown subtype/lineage. A(H1N1)pdm09 viruses belonged to clade-6B, distinguished by a K163Q substitution, but remained antigenically-similar to A/California/07/2009-like vaccine with adjusted-VE of 71%(95%CI=58-80%). Most (83%) B/Yamagata-lineage viruses clustered phylogenetically with the prior 2012-13 season's B/Wisconsin/01/2010-like clade-3 vaccine-strain while only 17% clustered with the current 2013-14 season's B/Massachusetts/02/2012-like clade-2 vaccine-strain. B/Yamagata-lineage adjusted-VE was 73%(95%CI=56-83%), lower with partial calendar-time adjustment for clade-mismatched B/Wisconsin/01/2010-like (VE=63%;95%CI=41-77%) versus clade-matched B/Massachusetts/02/2012-like (VE=88%;95%CI=48-97%) viruses. No H3N2 viruses clustered with the A/Texas/50/2012-like clade-3C.1 vaccine-strain, and more than half were antigenically-mismatched but sparse data did not support VE.
[h=4]CONCLUSIONS:[/h] VE corresponded with antigenically-conserved A(H1N1)pdm09 and lineage-matched B/Yamagata viruses with clade-level variation. Surveillance linking genotypic, phenotypic and epidemiologic measures of vaccine-virus relatedness and effectiveness could better inform predictions of vaccine performance and reformulation.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25784728 [PubMed - as supplied by publisher]
[h=1]Integrated sentinel surveillance linking genetic, antigenic and epidemiologic monitoring of influenza vaccine-virus relatedness and effectiveness, 2013-14 season.[/h] Skowronski DM[SUP]1[/SUP], Chambers C[SUP]2[/SUP], Sabaiduc S[SUP]2[/SUP], De Serres G[SUP]3[/SUP], Winter AL[SUP]4[/SUP], Dickinson JA[SUP]5[/SUP], Gubbay J[SUP]6[/SUP], Fonseca K[SUP]7[/SUP], Charest H[SUP]8[/SUP], Krajden M[SUP]9[/SUP], Petric M[SUP]10[/SUP], Mahmud SM[SUP]11[/SUP], Van Caeseele P[SUP]12[/SUP], Bastien N[SUP]13[/SUP], Eshaghi A[SUP]4[/SUP], Li Y[SUP]14[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Canada's Sentinel Physician Surveillance Network (SPSN) links genetic, antigenic and vaccine effectiveness (VE) measures in an integrated platform of influenza monitoring, described here for the 2013-14 season of resurgent A(H1N1)pdm09 and late-season influenza B activity.
[h=4]METHODS:[/h] VE was estimated as [1-OddsRatio]x100% comparing vaccination status between influenza test-positive cases and test-negative controls. Vaccine-virus relatedness was assessed by genomic sequence analysis and hemagglutination-inhibition assay.
[h=4]RESULTS:[/h] Analyses included 1037 controls (33%vaccinated) and 663 cases (15%vaccinated): 415 A(H1N1)pdm09, 15 A(H3N2), 191 B/Yamagata-lineage, 6 B/Victoria-lineage, 36 unknown subtype/lineage. A(H1N1)pdm09 viruses belonged to clade-6B, distinguished by a K163Q substitution, but remained antigenically-similar to A/California/07/2009-like vaccine with adjusted-VE of 71%(95%CI=58-80%). Most (83%) B/Yamagata-lineage viruses clustered phylogenetically with the prior 2012-13 season's B/Wisconsin/01/2010-like clade-3 vaccine-strain while only 17% clustered with the current 2013-14 season's B/Massachusetts/02/2012-like clade-2 vaccine-strain. B/Yamagata-lineage adjusted-VE was 73%(95%CI=56-83%), lower with partial calendar-time adjustment for clade-mismatched B/Wisconsin/01/2010-like (VE=63%;95%CI=41-77%) versus clade-matched B/Massachusetts/02/2012-like (VE=88%;95%CI=48-97%) viruses. No H3N2 viruses clustered with the A/Texas/50/2012-like clade-3C.1 vaccine-strain, and more than half were antigenically-mismatched but sparse data did not support VE.
[h=4]CONCLUSIONS:[/h] VE corresponded with antigenically-conserved A(H1N1)pdm09 and lineage-matched B/Yamagata viruses with clade-level variation. Surveillance linking genotypic, phenotypic and epidemiologic measures of vaccine-virus relatedness and effectiveness could better inform predictions of vaccine performance and reformulation.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25784728 [PubMed - as supplied by publisher]