tetano
Editor, Senior Moderator
Int J Stroke
. 2022 Jul 7;17474930221114561.
doi: 10.1177/17474930221114561. Online ahead of print.
New Cardiovascular Events in the Convalescent Period Among Survivors of SARS-CoV-2 Infection
Adnan Qureshi[SUP] 1 [/SUP], William I Baskett[SUP] 2 [/SUP], Wei Huang[SUP] 1 [/SUP], Yasemin Akinci[SUP] 1 [/SUP], Fareed Suri[SUP] 3 [/SUP], Syed Hasan Naqvi[SUP] 4 [/SUP], Brandi R French[SUP] 5 [/SUP], Farhan Siddiq[SUP] 6 [/SUP], Camilo Gomez[SUP] 1 [/SUP], Chi-Ren Shyu[SUP] 2 7 8 [/SUP]
Affiliations
Abstract
Background: Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have an increased risk of acute cardiovascular events in the convalescent period.
Aims: To determine whether patients with pneumonia associated with SARS-CoV-2 infection have an increased risk of cardiovascular events during the convalescent period.
Methods: We analyzed 10,691 hospitalized adult patients diagnosed with pneumonia associated with SARS-CoV-2 infection and contemporary matched controls of patients diagnosed with pneumonia unrelated to SARS-CoV-2 infection. The risk of new cardiovascular events following >30 days after reference hospitalization admission (convalescent period) was ascertained using Cox proportional hazards regression analysis to adjust for potential confounders.
Results: Among 10,691 patients with pneumonia associated with SARS-CoV-2 infection, 697 patients (5.8%; 95% CI, 5.4%-6.2%) developed new cardiovascular events in the convalescent period (median time interval of 218 days post reference encounter admission; interquartile range Q1=117 days, Q3=313 days). The risk of new cardiovascular events was not significantly higher with pneumonia associated with SARS-CoV-2 infection compared with pneumonia unrelated to SARS-CoV-2 infection (hazard ratio
, 0.90, 95% CI, 0.80-1.02) after adjustment for potential confounders. In addition, no significant difference in the rate of a new ischemic stroke (HR, 0.84; 95% CI, 0.70-1.02) or ischemic heart disease (HR, 1.00; 95% CI, 0.87-1.15) was observed between the SARS-CoV-2 infection-associated pneumonia group and the non-SARS-CoV-2 infection-associated pneumonia group.
Conclusions: Our study suggests that new cardiovascular events rate in the convalescent period among pneumonia patients associated with SARS-CoV-2 infection was not significantly higher than the rate seen with other pneumonias.
Keywords: SARS-CoV-2; Stroke; cardiovascular events; coronavirus disease; pneumonia; severe acute respiratory syndrome coronavirus 2.
. 2022 Jul 7;17474930221114561.
doi: 10.1177/17474930221114561. Online ahead of print.
New Cardiovascular Events in the Convalescent Period Among Survivors of SARS-CoV-2 Infection
Adnan Qureshi[SUP] 1 [/SUP], William I Baskett[SUP] 2 [/SUP], Wei Huang[SUP] 1 [/SUP], Yasemin Akinci[SUP] 1 [/SUP], Fareed Suri[SUP] 3 [/SUP], Syed Hasan Naqvi[SUP] 4 [/SUP], Brandi R French[SUP] 5 [/SUP], Farhan Siddiq[SUP] 6 [/SUP], Camilo Gomez[SUP] 1 [/SUP], Chi-Ren Shyu[SUP] 2 7 8 [/SUP]
Affiliations
- PMID: 35796639
- DOI: 10.1177/17474930221114561
Abstract
Background: Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have an increased risk of acute cardiovascular events in the convalescent period.
Aims: To determine whether patients with pneumonia associated with SARS-CoV-2 infection have an increased risk of cardiovascular events during the convalescent period.
Methods: We analyzed 10,691 hospitalized adult patients diagnosed with pneumonia associated with SARS-CoV-2 infection and contemporary matched controls of patients diagnosed with pneumonia unrelated to SARS-CoV-2 infection. The risk of new cardiovascular events following >30 days after reference hospitalization admission (convalescent period) was ascertained using Cox proportional hazards regression analysis to adjust for potential confounders.
Results: Among 10,691 patients with pneumonia associated with SARS-CoV-2 infection, 697 patients (5.8%; 95% CI, 5.4%-6.2%) developed new cardiovascular events in the convalescent period (median time interval of 218 days post reference encounter admission; interquartile range Q1=117 days, Q3=313 days). The risk of new cardiovascular events was not significantly higher with pneumonia associated with SARS-CoV-2 infection compared with pneumonia unrelated to SARS-CoV-2 infection (hazard ratio
, 0.90, 95% CI, 0.80-1.02) after adjustment for potential confounders. In addition, no significant difference in the rate of a new ischemic stroke (HR, 0.84; 95% CI, 0.70-1.02) or ischemic heart disease (HR, 1.00; 95% CI, 0.87-1.15) was observed between the SARS-CoV-2 infection-associated pneumonia group and the non-SARS-CoV-2 infection-associated pneumonia group.
Conclusions: Our study suggests that new cardiovascular events rate in the convalescent period among pneumonia patients associated with SARS-CoV-2 infection was not significantly higher than the rate seen with other pneumonias.
Keywords: SARS-CoV-2; Stroke; cardiovascular events; coronavirus disease; pneumonia; severe acute respiratory syndrome coronavirus 2.