tetano
Editor, Senior Moderator
Int J Stroke. 2020 Apr 20:1747493020921664. doi: 10.1177/1747493020921664. [Epub ahead of print]
Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature.
Aggarwal G[SUP]1[/SUP], Lippi G[SUP]2[/SUP], Michael Henry B[SUP]3[/SUP].
Author information
Abstract
INTRODUCTION:
There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown.
METHOD:
We pooled studies from published literature to assess the association of a history of stroke with outcomes in patients with COVID-19.
RESULTS:
A pooled analysis of 4 studies showed a ∼2.5-fold increase in odds of severe COVID-19. While a trend was observed, there was no statistically significant association of stroke with mortality in patients with COVID-19 infection.
DISCUSSION:
Our findings are limited by a small number of studies and sample size.
CONCLUSION:
There is a ∼2.5-fold increase in odds of severe COVID-19 illness with a history of cerebrovascular disease.
KEYWORDS:
COVID-19; Cerebrovascular disease; Coronavirus
PMID:32310015DOI:10.1177/1747493020921664
Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature.
Aggarwal G[SUP]1[/SUP], Lippi G[SUP]2[/SUP], Michael Henry B[SUP]3[/SUP].
Author information
Abstract
INTRODUCTION:
There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown.
METHOD:
We pooled studies from published literature to assess the association of a history of stroke with outcomes in patients with COVID-19.
RESULTS:
A pooled analysis of 4 studies showed a ∼2.5-fold increase in odds of severe COVID-19. While a trend was observed, there was no statistically significant association of stroke with mortality in patients with COVID-19 infection.
DISCUSSION:
Our findings are limited by a small number of studies and sample size.
CONCLUSION:
There is a ∼2.5-fold increase in odds of severe COVID-19 illness with a history of cerebrovascular disease.
KEYWORDS:
COVID-19; Cerebrovascular disease; Coronavirus
PMID:32310015DOI:10.1177/1747493020921664