tetano
Editor, Senior Moderator
Int J Public Health
. 2023 Oct 2:68:1605370.
doi: 10.3389/ijph.2023.1605370. eCollection 2023. Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in Taiwan
Hung-Chang Jong[SUP] #[/SUP][SUP] 1 [/SUP], Jing-Quan Zheng[SUP] #[/SUP][SUP] 2 3 4 [/SUP], Cai-Mei Zheng[SUP] 5 6 7 [/SUP], Cheng-Hsin Lin[SUP] 8 9 10 [/SUP], Chun-Chih Chiu[SUP] 1 8 11 [/SUP], Min-Huei Hsu[SUP] 12 13 [/SUP], Yu-Ann Fang[SUP] 1 8 11 [/SUP], Wen-Rui Hao[SUP] 1 8 11 [/SUP], Chun-Chao Chen[SUP] 1 8 11 14 [/SUP], Tsung Yeh Yang[SUP] 1 8 11 [/SUP], Kang-Yun Lee[SUP] 2 3 4 [/SUP], Ju-Chi Liu[SUP] 1 8 11 [/SUP]
Affiliations
Objectives: Lung cancer is a main contributor to all newly diagnosed cancers worldwide. The chemoprotective effect of the influenza vaccine among patients with hypertension remains unclear. Methods: A total of 37,022 patients with hypertension were retrospectively enrolled from the Taiwan National Health Insurance Research Database. These patients were further divided into a vaccinated group (n = 15,697) and an unvaccinated group (n = 21,325). Results: After adjusting for sex, age, comorbidities, medications, level of urbanization and monthly income, vaccinated patients had a significantly lower risk of lung cancer occurrence than unvaccinated patients (adjusted hazard ratio [aHR]: 0.56, 95% confidence interval [CI]: 0.47-0.67). A potential protective effect was observed for both sexes and in the elderly age group. With a greater total number of vaccinations, a potentially greater protective effect was observed (aHR: 0.75, 95% CI 0.60-0.95; aHR: 0.66, 95% CI: 0.53-0.82; aHR: 0.26, 95% CI: 0.19-0.36, after receiving 1, 2-3 and ≥4 vaccinations, respectively). Conclusion: Influenza vaccination was associated with a lower risk of lung cancer among patients with hypertension. The potentially chemoprotective effect appeared to be dose dependent.
Keywords: hypertension; influenza vaccination; lung cancer; malignancy; prevention.
. 2023 Oct 2:68:1605370.
doi: 10.3389/ijph.2023.1605370. eCollection 2023. Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in Taiwan
Hung-Chang Jong[SUP] #[/SUP][SUP] 1 [/SUP], Jing-Quan Zheng[SUP] #[/SUP][SUP] 2 3 4 [/SUP], Cai-Mei Zheng[SUP] 5 6 7 [/SUP], Cheng-Hsin Lin[SUP] 8 9 10 [/SUP], Chun-Chih Chiu[SUP] 1 8 11 [/SUP], Min-Huei Hsu[SUP] 12 13 [/SUP], Yu-Ann Fang[SUP] 1 8 11 [/SUP], Wen-Rui Hao[SUP] 1 8 11 [/SUP], Chun-Chao Chen[SUP] 1 8 11 14 [/SUP], Tsung Yeh Yang[SUP] 1 8 11 [/SUP], Kang-Yun Lee[SUP] 2 3 4 [/SUP], Ju-Chi Liu[SUP] 1 8 11 [/SUP]
Affiliations
- PMID: 37849687
- PMCID: PMC10577198
- DOI: 10.3389/ijph.2023.1605370
Objectives: Lung cancer is a main contributor to all newly diagnosed cancers worldwide. The chemoprotective effect of the influenza vaccine among patients with hypertension remains unclear. Methods: A total of 37,022 patients with hypertension were retrospectively enrolled from the Taiwan National Health Insurance Research Database. These patients were further divided into a vaccinated group (n = 15,697) and an unvaccinated group (n = 21,325). Results: After adjusting for sex, age, comorbidities, medications, level of urbanization and monthly income, vaccinated patients had a significantly lower risk of lung cancer occurrence than unvaccinated patients (adjusted hazard ratio [aHR]: 0.56, 95% confidence interval [CI]: 0.47-0.67). A potential protective effect was observed for both sexes and in the elderly age group. With a greater total number of vaccinations, a potentially greater protective effect was observed (aHR: 0.75, 95% CI 0.60-0.95; aHR: 0.66, 95% CI: 0.53-0.82; aHR: 0.26, 95% CI: 0.19-0.36, after receiving 1, 2-3 and ≥4 vaccinations, respectively). Conclusion: Influenza vaccination was associated with a lower risk of lung cancer among patients with hypertension. The potentially chemoprotective effect appeared to be dose dependent.
Keywords: hypertension; influenza vaccination; lung cancer; malignancy; prevention.