tetano
Editor, Senior Moderator
Int J Neurosci
. 2020 Nov 11;1-11.
doi: 10.1080/00207454.2020.1849193. Online ahead of print.
Neurological manifestations of Coronavirus Infections: Role of Angiotensin-Converting Enzyme 2 in COVID-19
Negin Parsamanesh[SUP] 1 [/SUP], Aiyoub Pezeshgi[SUP] 1 2 [/SUP], Mina Hemmati[SUP] 3 [/SUP], Maryam Jameshorani[SUP] 1 2 [/SUP], Ehsan Saboory[SUP] 1 [/SUP]
Affiliations
Abstract
In December 2019, a highly pathogenic coronavirus called SARS-CoV-2 (formerly identified as2019-nCoV) appeared in Wuhan, China, and has since been spreading rapidly around the world.The most specific manifestation of SARS-CoV-2 patients is pulmonary distress, and several patients admitted to intensive care units were not able to breathe spontaneously.In addition, the SARS-CoV-2 outbreak has a significant effect on nervous systems and may even lead to serious neurological damage.The neuroinvasive pathobiology is still not fully elucidated and thus the effect of CoV infections on the nervous system needs to be explored. The spike protein of the virus and the angiotensin-converting enzyme 2 (ACE2) lead to the presence of both SARS-CoV and SARS-CoV-2 in the cells and, subsequently,decreased ACE2 expression. The therapeutic possibilities of ACE2 antibody, ACE2-derived peptides, and small molecule blockers of ACE2 include a receptor-binding domain blocking approach. Hence,future studies of ACE2 may be very helpful in discovering a therapy for SARS-CoV-2. Here, we review the neurological manifestations of this infection and the potential of ACE2 in the nervous system.
Keywords: Angiotensin-Converting Enzyme 2; COVID-19; Nervous Systems.
. 2020 Nov 11;1-11.
doi: 10.1080/00207454.2020.1849193. Online ahead of print.
Neurological manifestations of Coronavirus Infections: Role of Angiotensin-Converting Enzyme 2 in COVID-19
Negin Parsamanesh[SUP] 1 [/SUP], Aiyoub Pezeshgi[SUP] 1 2 [/SUP], Mina Hemmati[SUP] 3 [/SUP], Maryam Jameshorani[SUP] 1 2 [/SUP], Ehsan Saboory[SUP] 1 [/SUP]
Affiliations
- PMID: 33175635
- DOI: 10.1080/00207454.2020.1849193
Abstract
In December 2019, a highly pathogenic coronavirus called SARS-CoV-2 (formerly identified as2019-nCoV) appeared in Wuhan, China, and has since been spreading rapidly around the world.The most specific manifestation of SARS-CoV-2 patients is pulmonary distress, and several patients admitted to intensive care units were not able to breathe spontaneously.In addition, the SARS-CoV-2 outbreak has a significant effect on nervous systems and may even lead to serious neurological damage.The neuroinvasive pathobiology is still not fully elucidated and thus the effect of CoV infections on the nervous system needs to be explored. The spike protein of the virus and the angiotensin-converting enzyme 2 (ACE2) lead to the presence of both SARS-CoV and SARS-CoV-2 in the cells and, subsequently,decreased ACE2 expression. The therapeutic possibilities of ACE2 antibody, ACE2-derived peptides, and small molecule blockers of ACE2 include a receptor-binding domain blocking approach. Hence,future studies of ACE2 may be very helpful in discovering a therapy for SARS-CoV-2. Here, we review the neurological manifestations of this infection and the potential of ACE2 in the nervous system.
Keywords: Angiotensin-Converting Enzyme 2; COVID-19; Nervous Systems.