tetano
Editor, Senior Moderator
Int J Mol Sci
. 2021 Apr 19;22(8):4242.
doi: 10.3390/ijms22084242.
Structure and Activities of the NS1 Influenza Protein and Progress in the Development of Small-Molecule Drugs
Hyeon Jin Kim[SUP] 1 [/SUP], Mi Suk Jeong[SUP] 2 [/SUP], Se Bok Jang[SUP] 1 [/SUP]
Affiliations
Abstract
The influenza virus causes human disease on a global scale and significant morbidity and mortality. The existing vaccination regime remains vulnerable to antigenic drift, and more seriously, a small number of viral mutations could lead to drug resistance. Therefore, the development of a new additional therapeutic small molecule-based anti-influenza virus is urgently required. The NS1 influenza gene plays a pivotal role in the suppression of host antiviral responses, especially by inhibiting interferon (IFN) production and the activities of antiviral proteins, such as dsRNA-dependent serine/threonine-protein kinase R (PKR) and 2'-5'-oligoadenylate synthetase (OAS)/RNase L. NS1 also modulates important aspects of viral RNA replication, viral protein synthesis, and virus replication cycle. Taken together, small molecules that target NS1 are believed to offer a means of developing new anti-influenza drugs.
Keywords: NS1; drug; influenza virus A; inhibitor; small molecule.
. 2021 Apr 19;22(8):4242.
doi: 10.3390/ijms22084242.
Structure and Activities of the NS1 Influenza Protein and Progress in the Development of Small-Molecule Drugs
Hyeon Jin Kim[SUP] 1 [/SUP], Mi Suk Jeong[SUP] 2 [/SUP], Se Bok Jang[SUP] 1 [/SUP]
Affiliations
- PMID: 33921888
- DOI: 10.3390/ijms22084242
Abstract
The influenza virus causes human disease on a global scale and significant morbidity and mortality. The existing vaccination regime remains vulnerable to antigenic drift, and more seriously, a small number of viral mutations could lead to drug resistance. Therefore, the development of a new additional therapeutic small molecule-based anti-influenza virus is urgently required. The NS1 influenza gene plays a pivotal role in the suppression of host antiviral responses, especially by inhibiting interferon (IFN) production and the activities of antiviral proteins, such as dsRNA-dependent serine/threonine-protein kinase R (PKR) and 2'-5'-oligoadenylate synthetase (OAS)/RNase L. NS1 also modulates important aspects of viral RNA replication, viral protein synthesis, and virus replication cycle. Taken together, small molecules that target NS1 are believed to offer a means of developing new anti-influenza drugs.
Keywords: NS1; drug; influenza virus A; inhibitor; small molecule.