tetano
Editor, Senior Moderator
Int J Mol Sci
. 2021 Jan 23;22(3):1118.
doi: 10.3390/ijms22031118.
A Missing Link: Engagements of Dendritic Cells in the Pathogenesis of SARS-CoV-2 Infections
Abdulaziz Alamri[SUP] 1 [/SUP], Derek Fisk[SUP] 1 [/SUP], Deepak Upreti[SUP] 2 [/SUP], Sam K P Kung[SUP] 1 [/SUP]
Affiliations
Abstract
Dendritic cells (DC) connect the innate and adaptive arms of the immune system and carry out numerous roles that are significant in the context of viral disease. Their functions include the control of inflammatory responses, the promotion of tolerance, cross-presentation, immune cell recruitment and the production of antiviral cytokines. Based primarily on the available literature that characterizes the behaviour of many DC subsets during Severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19), we speculated possible mechanisms through which DC could contribute to COVID-19 immune responses, such as dissemination of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to lymph nodes, mounting dysfunctional inteferon responses and T cell immunity in patients. We highlighted gaps of knowledge in our understanding of DC in COVID-19 pathogenesis and discussed current pre-clinical development of therapies for COVID-19.
Keywords: COVID-19; SARS-CoV2; dendritic cells; immunopathology; therapy.
. 2021 Jan 23;22(3):1118.
doi: 10.3390/ijms22031118.
A Missing Link: Engagements of Dendritic Cells in the Pathogenesis of SARS-CoV-2 Infections
Abdulaziz Alamri[SUP] 1 [/SUP], Derek Fisk[SUP] 1 [/SUP], Deepak Upreti[SUP] 2 [/SUP], Sam K P Kung[SUP] 1 [/SUP]
Affiliations
- PMID: 33498725
- DOI: 10.3390/ijms22031118
Abstract
Dendritic cells (DC) connect the innate and adaptive arms of the immune system and carry out numerous roles that are significant in the context of viral disease. Their functions include the control of inflammatory responses, the promotion of tolerance, cross-presentation, immune cell recruitment and the production of antiviral cytokines. Based primarily on the available literature that characterizes the behaviour of many DC subsets during Severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19), we speculated possible mechanisms through which DC could contribute to COVID-19 immune responses, such as dissemination of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to lymph nodes, mounting dysfunctional inteferon responses and T cell immunity in patients. We highlighted gaps of knowledge in our understanding of DC in COVID-19 pathogenesis and discussed current pre-clinical development of therapies for COVID-19.
Keywords: COVID-19; SARS-CoV2; dendritic cells; immunopathology; therapy.