tetano
Editor, Senior Moderator
Int J Microbiol
. 2023 Jan 4;2023:4540287.
doi: 10.1155/2023/4540287. eCollection 2023.
The Relation between ACE Gene Polymorphism and the Severity of COVID-19 Infection
Yara El-Sayed Marei[SUP] 1 [/SUP], Ahmed Abdallah Bayoumy[SUP] 2 [/SUP], Hassnaa Mohamed Abulazm Nassar[SUP] 3 [/SUP], Bassam Mansour[SUP] 4 [/SUP], Asmaa Bakeir Hamady[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: The coronavirus disease 2019 (COVID-19) pandemic, which emerged in China at the end of 2019, rapidly spread worldwide. The angiotensin-converting enzyme (ACE) gene contains an insertion/deletion (I/D) polymorphism that leads to a higher serum ACE level which is associated with several diseases and also with a high mortality rate in SARS. Therefore, this study aimed at assessing the association between ACE gene polymorphism and the risk and severity of COVID-19 disease in patients. Methodology. Forty-five SARS-CoV-2 infected patients and another random control group of 45 healthy individuals were included. The detection of ACE I/D gene polymorphism in both groups was done by PCR.
Results: 53% of infected patients with SARS-CoV-2 had an ACE deletion/deletion genotype (D/D), 27% had an ACE deletion/insertion genotype (D/I), and 20% had an ACE insertion/insertion genotype (I/I). On the one hand, the D/D variant was significantly detected in the COVID-19 patients compared to the control subjects, whereas the I/I variant was significantly detected in the control subjects compared to the COVID-19 patients (p = 0.004). The D/D variant subgroup showed the lowest lymphocytic count compared to the D/I or I/I subgroups. In addition, the C-reactive protein was significantly higher and the oxygen saturation was significantly lower in patients with the D/D allele compared to the other subgroups.
Conclusions: ACE gene polymorphism, particularly the DD genotype, was observed to affect the severity of COVID-19 infection.
. 2023 Jan 4;2023:4540287.
doi: 10.1155/2023/4540287. eCollection 2023.
The Relation between ACE Gene Polymorphism and the Severity of COVID-19 Infection
Yara El-Sayed Marei[SUP] 1 [/SUP], Ahmed Abdallah Bayoumy[SUP] 2 [/SUP], Hassnaa Mohamed Abulazm Nassar[SUP] 3 [/SUP], Bassam Mansour[SUP] 4 [/SUP], Asmaa Bakeir Hamady[SUP] 1 [/SUP]
Affiliations
- PMID: 36644496
- PMCID: PMC9833908
- DOI: 10.1155/2023/4540287
Abstract
Introduction: The coronavirus disease 2019 (COVID-19) pandemic, which emerged in China at the end of 2019, rapidly spread worldwide. The angiotensin-converting enzyme (ACE) gene contains an insertion/deletion (I/D) polymorphism that leads to a higher serum ACE level which is associated with several diseases and also with a high mortality rate in SARS. Therefore, this study aimed at assessing the association between ACE gene polymorphism and the risk and severity of COVID-19 disease in patients. Methodology. Forty-five SARS-CoV-2 infected patients and another random control group of 45 healthy individuals were included. The detection of ACE I/D gene polymorphism in both groups was done by PCR.
Results: 53% of infected patients with SARS-CoV-2 had an ACE deletion/deletion genotype (D/D), 27% had an ACE deletion/insertion genotype (D/I), and 20% had an ACE insertion/insertion genotype (I/I). On the one hand, the D/D variant was significantly detected in the COVID-19 patients compared to the control subjects, whereas the I/I variant was significantly detected in the control subjects compared to the COVID-19 patients (p = 0.004). The D/D variant subgroup showed the lowest lymphocytic count compared to the D/I or I/I subgroups. In addition, the C-reactive protein was significantly higher and the oxygen saturation was significantly lower in patients with the D/D allele compared to the other subgroups.
Conclusions: ACE gene polymorphism, particularly the DD genotype, was observed to affect the severity of COVID-19 infection.