tetano
Editor, Senior Moderator
Int J Med Sci
. 2021 Jan 14;18(5):1207-1215.
doi: 10.7150/ijms.47494. eCollection 2021.
Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19
Rongrong Ding[SUP] 1 [/SUP], Zongguo Yang[SUP] 2 [/SUP], Dan Huang[SUP] 1 [/SUP], Yanbing Wang[SUP] 1 [/SUP], Xiufen Li[SUP] 1 [/SUP], Xinlan Zhou[SUP] 1 [/SUP], Li Yan[SUP] 1 [/SUP], Wei Lu[SUP] 1 [/SUP], Zhanqing Zhang[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: This study aimed to identify the predictive value of simple markers in routine blood and coagulation tests for the severity of coronavirus disease 2019 (COVID-19). Methods: A total of 311 consecutive COVID-19 patients, including 281 patients with mild/moderate COVID-19 and 30 patients with severe/life-threatening COVID-19, were retrospectively enrolled. Logistic modeling and ROC curve analyses were used to assess the indexes for identifying disease severity. Results: Lymphocyte and eosinophil counts of COVID-19 patients in the severe/life-threatening group were significantly lower than those of patients in the mild/moderate group (P < 0.001). Coagulation parameters, high-sensitivity C-reactive protein (hsCRP) levels and procalcitonin levels were higher in the severe/life-threatening group compared with the mild/moderate group (all P < 0.05). Univariate and multivariate logistic models revealed that hsCRP and fibrinogen degradation products (FDPs) were predictors of severe COVID-19 (OR = 1.072, P = 0.036; and OR = 1.831, P = 0.036, respectively). The AUROCs of hsCRP and FDP for predicting severe/life-threatening COVID-19 were 0.850 and 0.766, respectively. The optimal cutoffs of hsCRP and FDP for the severe/life-threatening type of COVID-19 were 22.41 mg/L and 0.95 ?g/ml, respectively. Conclusion: Serum CRP and FDP levels are positively related to the severity of COVID-19. This finding indicates that CRP and FDP levels may potentially be used as early predictors for severe illness and help physicians triage numerous patients in a short time.
Keywords: COVID-19; Coronavirus disease 2019; FDP; fibrinogen degradation products; highly sensitive C-reactive protein.
. 2021 Jan 14;18(5):1207-1215.
doi: 10.7150/ijms.47494. eCollection 2021.
Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19
Rongrong Ding[SUP] 1 [/SUP], Zongguo Yang[SUP] 2 [/SUP], Dan Huang[SUP] 1 [/SUP], Yanbing Wang[SUP] 1 [/SUP], Xiufen Li[SUP] 1 [/SUP], Xinlan Zhou[SUP] 1 [/SUP], Li Yan[SUP] 1 [/SUP], Wei Lu[SUP] 1 [/SUP], Zhanqing Zhang[SUP] 1 [/SUP]
Affiliations
- PMID: 33526982
- PMCID: PMC7847620
- DOI: 10.7150/ijms.47494
Abstract
Objective: This study aimed to identify the predictive value of simple markers in routine blood and coagulation tests for the severity of coronavirus disease 2019 (COVID-19). Methods: A total of 311 consecutive COVID-19 patients, including 281 patients with mild/moderate COVID-19 and 30 patients with severe/life-threatening COVID-19, were retrospectively enrolled. Logistic modeling and ROC curve analyses were used to assess the indexes for identifying disease severity. Results: Lymphocyte and eosinophil counts of COVID-19 patients in the severe/life-threatening group were significantly lower than those of patients in the mild/moderate group (P < 0.001). Coagulation parameters, high-sensitivity C-reactive protein (hsCRP) levels and procalcitonin levels were higher in the severe/life-threatening group compared with the mild/moderate group (all P < 0.05). Univariate and multivariate logistic models revealed that hsCRP and fibrinogen degradation products (FDPs) were predictors of severe COVID-19 (OR = 1.072, P = 0.036; and OR = 1.831, P = 0.036, respectively). The AUROCs of hsCRP and FDP for predicting severe/life-threatening COVID-19 were 0.850 and 0.766, respectively. The optimal cutoffs of hsCRP and FDP for the severe/life-threatening type of COVID-19 were 22.41 mg/L and 0.95 ?g/ml, respectively. Conclusion: Serum CRP and FDP levels are positively related to the severity of COVID-19. This finding indicates that CRP and FDP levels may potentially be used as early predictors for severe illness and help physicians triage numerous patients in a short time.
Keywords: COVID-19; Coronavirus disease 2019; FDP; fibrinogen degradation products; highly sensitive C-reactive protein.