tetano
Editor, Senior Moderator
Int J Infect Dis
. 2023 Mar 1;S1201-9712(23)00071-1.
doi: 10.1016/j.ijid.2023.02.022. Online ahead of print.
Vaccination from the early second trimester onwards gives a robust SARS-CoV-2 antibody response throughout pregnancy and provides antibodies for the neonate
S J M Zilver[SUP] 1 [/SUP], C J M de Groot[SUP] 2 [/SUP], M Grobben[SUP] 3 [/SUP], S Remmelzwaal[SUP] 4 [/SUP], E Burgers[SUP] 5 [/SUP], D Nunez Velasco[SUP] 6 [/SUP], H G Juncker[SUP] 7 [/SUP], B J van Keulen[SUP] 7 [/SUP], J B van Goudoever[SUP] 7 [/SUP], R A de Leeuw[SUP] 6 [/SUP], M J van Gils[SUP] 3 [/SUP], C Ris-Stalpers[SUP] 2 [/SUP], E van Leeuwen[SUP] 2 [/SUP]
Affiliations
Abstract
Objectives: Preventative measures against Coronavirus Disease 2019 (COVID-19) are essential for pregnant women; they are particularly vulnerable to emerging infectious pathogens due to alterations in their physiology. We aimed to determine the optimum timing of vaccination to protect pregnant women and their neonates from COVID-19.
Methods: A prospective observational longitudinal cohort study in pregnant women who received COVID-19 vaccination. We collected blood samples to evaluate levels of anti-spike, receptor binding domain (RBD) and nucleocapsid antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) before vaccination, and 15 days after first and second vaccination. We determined neutralizing antibodies from mother-infant dyads in maternal and umbilical cord blood at birth. If available, IgA was measured in human milk.
Results: We included 178 pregnant women. Median anti-spike IgG levels increased significantly from 1.8 to 5431 binding antibody units/milliliter (BAU/mL) and RBD from 6 to 4466 BAU/mL. Virus neutralization showed similar results between different weeks' gestations at vaccination (p > 0.3).
Conclusions: We advise vaccination in the early second trimester of pregnancy for the optimum balance between maternal antibody response and placental antibody transfer to the neonate.
. 2023 Mar 1;S1201-9712(23)00071-1.
doi: 10.1016/j.ijid.2023.02.022. Online ahead of print.
Vaccination from the early second trimester onwards gives a robust SARS-CoV-2 antibody response throughout pregnancy and provides antibodies for the neonate
S J M Zilver[SUP] 1 [/SUP], C J M de Groot[SUP] 2 [/SUP], M Grobben[SUP] 3 [/SUP], S Remmelzwaal[SUP] 4 [/SUP], E Burgers[SUP] 5 [/SUP], D Nunez Velasco[SUP] 6 [/SUP], H G Juncker[SUP] 7 [/SUP], B J van Keulen[SUP] 7 [/SUP], J B van Goudoever[SUP] 7 [/SUP], R A de Leeuw[SUP] 6 [/SUP], M J van Gils[SUP] 3 [/SUP], C Ris-Stalpers[SUP] 2 [/SUP], E van Leeuwen[SUP] 2 [/SUP]
Affiliations
- PMID: 36868302
- PMCID: PMC9977072
- DOI: 10.1016/j.ijid.2023.02.022
Abstract
Objectives: Preventative measures against Coronavirus Disease 2019 (COVID-19) are essential for pregnant women; they are particularly vulnerable to emerging infectious pathogens due to alterations in their physiology. We aimed to determine the optimum timing of vaccination to protect pregnant women and their neonates from COVID-19.
Methods: A prospective observational longitudinal cohort study in pregnant women who received COVID-19 vaccination. We collected blood samples to evaluate levels of anti-spike, receptor binding domain (RBD) and nucleocapsid antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) before vaccination, and 15 days after first and second vaccination. We determined neutralizing antibodies from mother-infant dyads in maternal and umbilical cord blood at birth. If available, IgA was measured in human milk.
Results: We included 178 pregnant women. Median anti-spike IgG levels increased significantly from 1.8 to 5431 binding antibody units/milliliter (BAU/mL) and RBD from 6 to 4466 BAU/mL. Virus neutralization showed similar results between different weeks' gestations at vaccination (p > 0.3).
Conclusions: We advise vaccination in the early second trimester of pregnancy for the optimum balance between maternal antibody response and placental antibody transfer to the neonate.