tetano
Editor, Senior Moderator
Int J Infect Dis
. 2022 Feb 16;S1201-9712(22)00101-1.
doi: 10.1016/j.ijid.2022.02.024. Online ahead of print.
Urine sediment findings were milder in patients with COVID-19-associated renal injuries than in those with non-COVID-19-associated renal injuries
Yoshifumi Morita[SUP] 1 [/SUP], Makoto Kurano[SUP] 2 [/SUP], Daisuke Jubishi[SUP] 3 [/SUP], Mahoko Ikeda[SUP] 4 [/SUP], Koh Okamoto[SUP] 3 [/SUP], Masami Tanaka[SUP] 1 [/SUP], Sohei Harada[SUP] 5 [/SUP], Shu Okugawa[SUP] 3 [/SUP], Kyoji Moriya[SUP] 4 [/SUP], Yutaka Yatomi[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Acute renal injury is an important complication of coronavirus disease 2019 (COVID-19). Both COVID-19-specific mechanisms, such as damage to the renal parenchyma by direct infection, and non-specific mechanisms, such as the pre-renal injury factors, have been proposed to be involved in COVID-19-associated renal injuries. In this study, we aimed to elucidate the characteristics of COVID-19-associated renal injuries, focusing mainly on urine sediment findings.
Methods: We compared the urine sediment findings and their associations with renal functions or urinary clinical parameters between COVID-19 subjects and non-COVID-19 subjects with acute renal injuries.
Results: We found that the number of urine sediment particles and the levels of N-acetyl-β-D-glucosaminidase, α1-microglobulin, liver type fatty acid-binding protein, and neutrophil gelatinase-associated lipocalin were associated with the severity of COVID-19. In addition, we observed that the number of granular casts, epithelial casts, waxy casts, and urinary chemical marker levels were lower in the COVID-19 subjects than non-COVID-19 subjects with acute renal injuries when the subjects were classified according to their renal function.
Conclusions: These results suggest that pre-renal injury factors might be largely involved in the pathogenesis of COVID-19-associated renal injuries, compared with non-COVID-19-associated renal injuries arising from surgery or sepsis.
Keywords: COVID-19; acute kidney injuries; urine sediment findings.
. 2022 Feb 16;S1201-9712(22)00101-1.
doi: 10.1016/j.ijid.2022.02.024. Online ahead of print.
Urine sediment findings were milder in patients with COVID-19-associated renal injuries than in those with non-COVID-19-associated renal injuries
Yoshifumi Morita[SUP] 1 [/SUP], Makoto Kurano[SUP] 2 [/SUP], Daisuke Jubishi[SUP] 3 [/SUP], Mahoko Ikeda[SUP] 4 [/SUP], Koh Okamoto[SUP] 3 [/SUP], Masami Tanaka[SUP] 1 [/SUP], Sohei Harada[SUP] 5 [/SUP], Shu Okugawa[SUP] 3 [/SUP], Kyoji Moriya[SUP] 4 [/SUP], Yutaka Yatomi[SUP] 6 [/SUP]
Affiliations
- PMID: 35182739
- DOI: 10.1016/j.ijid.2022.02.024
Abstract
Background: Acute renal injury is an important complication of coronavirus disease 2019 (COVID-19). Both COVID-19-specific mechanisms, such as damage to the renal parenchyma by direct infection, and non-specific mechanisms, such as the pre-renal injury factors, have been proposed to be involved in COVID-19-associated renal injuries. In this study, we aimed to elucidate the characteristics of COVID-19-associated renal injuries, focusing mainly on urine sediment findings.
Methods: We compared the urine sediment findings and their associations with renal functions or urinary clinical parameters between COVID-19 subjects and non-COVID-19 subjects with acute renal injuries.
Results: We found that the number of urine sediment particles and the levels of N-acetyl-β-D-glucosaminidase, α1-microglobulin, liver type fatty acid-binding protein, and neutrophil gelatinase-associated lipocalin were associated with the severity of COVID-19. In addition, we observed that the number of granular casts, epithelial casts, waxy casts, and urinary chemical marker levels were lower in the COVID-19 subjects than non-COVID-19 subjects with acute renal injuries when the subjects were classified according to their renal function.
Conclusions: These results suggest that pre-renal injury factors might be largely involved in the pathogenesis of COVID-19-associated renal injuries, compared with non-COVID-19-associated renal injuries arising from surgery or sepsis.
Keywords: COVID-19; acute kidney injuries; urine sediment findings.