tetano
Editor, Senior Moderator
Int J Infect Dis
. 2024 Apr 5:107024.
doi: 10.1016/j.ijid.2024.107024. Online ahead of print. Unveiling the role of preceding seasonal influenza in the development of bacteremic pneumococcal pneumonia in older adults before the COVID-19 pandemic in Japan
Kosuke Tamura[SUP] 1 [/SUP], Reiko Shimbashi[SUP] 2 [/SUP], Ayu Kasamatsu[SUP] 2 [/SUP], Bin Chang[SUP] 2 [/SUP], Kenji Gotoh[SUP] 3 [/SUP], Yoshinari Tanabe[SUP] 4 [/SUP], Koji Kuronuma[SUP] 5 [/SUP], Kengo Oshima[SUP] 6 [/SUP], Takaya Maruyama[SUP] 7 [/SUP], Masashi Nakamatsu[SUP] 8 [/SUP], Shuichi Abe[SUP] 9 [/SUP], Kei Kasahara[SUP] 10 [/SUP], Junichiro Nishi[SUP] 11 [/SUP], Yu Arakawa[SUP] 12 [/SUP], Yuki Kinjo[SUP] 13 [/SUP], Motoi Suzuki[SUP] 2 [/SUP], Yukihiro Akeda[SUP] 2 [/SUP], Kazunori Oishi[SUP] 14 [/SUP], Adult Ipd Study Group[SUP] 15 [/SUP]
Affiliations
Objective: We aimed to investigate the impact of preceding seasonal influenza on the clinical characteristics of adult patients with invasive pneumococcal disease (IPD) in Japan.
Methods: Data for 1,722 adult patients with IPD were analyzed before (2017-2019) and during the COVID-19 pandemic (2020-2022).
Results: Seasonal influenza epidemic disappeared soon after the emergence of the pandemic. Compared with that before the pandemic (66.7%), we observed a lower bacteremic pneumonia proportion in patients with IPD during the pandemic (55.6%). The clinical presentations of IPD cases significantly differed between those with and without preceding influenza. The proportion of bacteremic pneumonia was higher in IPD patients with preceding influenza than in those without in both younger (44.9% vs. 84.2%) and older adults (65.5% vs. 87.0%) before the pandemic. The case fatality rate was significantly higher in IPD patients with preceding influenza (28.3%) than in those without (15.3%) in older adults before the pandemic (P = 0.020). Male and aging are high risk factors for death in older patients with IPD who had preceding influenza.
Conclusion: Our study reveals that preceding seasonal influenza plays a role in the development of bacteremic pneumococcal pneumonia, increasing the risk of death in older adults.
Keywords: COVID-19; Invasive pneumococcal disease; adults; bacteremic pneumonia; influenza; preceding influenza.
. 2024 Apr 5:107024.
doi: 10.1016/j.ijid.2024.107024. Online ahead of print. Unveiling the role of preceding seasonal influenza in the development of bacteremic pneumococcal pneumonia in older adults before the COVID-19 pandemic in Japan
Kosuke Tamura[SUP] 1 [/SUP], Reiko Shimbashi[SUP] 2 [/SUP], Ayu Kasamatsu[SUP] 2 [/SUP], Bin Chang[SUP] 2 [/SUP], Kenji Gotoh[SUP] 3 [/SUP], Yoshinari Tanabe[SUP] 4 [/SUP], Koji Kuronuma[SUP] 5 [/SUP], Kengo Oshima[SUP] 6 [/SUP], Takaya Maruyama[SUP] 7 [/SUP], Masashi Nakamatsu[SUP] 8 [/SUP], Shuichi Abe[SUP] 9 [/SUP], Kei Kasahara[SUP] 10 [/SUP], Junichiro Nishi[SUP] 11 [/SUP], Yu Arakawa[SUP] 12 [/SUP], Yuki Kinjo[SUP] 13 [/SUP], Motoi Suzuki[SUP] 2 [/SUP], Yukihiro Akeda[SUP] 2 [/SUP], Kazunori Oishi[SUP] 14 [/SUP], Adult Ipd Study Group[SUP] 15 [/SUP]
Affiliations
- PMID: 38582146
- DOI: 10.1016/j.ijid.2024.107024
Objective: We aimed to investigate the impact of preceding seasonal influenza on the clinical characteristics of adult patients with invasive pneumococcal disease (IPD) in Japan.
Methods: Data for 1,722 adult patients with IPD were analyzed before (2017-2019) and during the COVID-19 pandemic (2020-2022).
Results: Seasonal influenza epidemic disappeared soon after the emergence of the pandemic. Compared with that before the pandemic (66.7%), we observed a lower bacteremic pneumonia proportion in patients with IPD during the pandemic (55.6%). The clinical presentations of IPD cases significantly differed between those with and without preceding influenza. The proportion of bacteremic pneumonia was higher in IPD patients with preceding influenza than in those without in both younger (44.9% vs. 84.2%) and older adults (65.5% vs. 87.0%) before the pandemic. The case fatality rate was significantly higher in IPD patients with preceding influenza (28.3%) than in those without (15.3%) in older adults before the pandemic (P = 0.020). Male and aging are high risk factors for death in older patients with IPD who had preceding influenza.
Conclusion: Our study reveals that preceding seasonal influenza plays a role in the development of bacteremic pneumococcal pneumonia, increasing the risk of death in older adults.
Keywords: COVID-19; Invasive pneumococcal disease; adults; bacteremic pneumonia; influenza; preceding influenza.