tetano
Editor, Senior Moderator
Int J Infect Dis
. 2021 Feb 1;S1201-9712(21)00075-8.
doi: 10.1016/j.ijid.2021.01.064. Online ahead of print.
The characteristics of 527 discharged COVID-19 patients undergoing long-term follow-up in China
Jintao Zhang[SUP] 1 [/SUP], Jiawei Xu[SUP] 1 [/SUP], Shengyu Zhou[SUP] 2 [/SUP], Chunting Wang[SUP] 3 [/SUP], Ximing Wang[SUP] 4 [/SUP], Wei Zhang[SUP] 5 [/SUP], Kang Ning[SUP] 6 [/SUP], Yun Pan[SUP] 1 [/SUP], Tian Liu[SUP] 2 [/SUP], Jiping Zhao[SUP] 2 [/SUP], Liang Dong[SUP] 7 [/SUP]
Affiliations
Abstract
Background: Almost a year after the outbreak of coronavirus disease 2019 (COVID-19), numerous hospitalized COVID-19 patients have recovered. However, little is known about the long-term follow-up (>2 months) of discharged patients.
Methods: We enrolled 527 discharged COVID-19 patients in a study from February 5 to March 11, 2020. These patients' basic characteristics, imaging features, nucleic acid detection results, and antibody levels were retrospectively reviewed.
Results: of the 527 discharged patients, 32 (6.1%) had re-detectable positive (RP) nucleic acid results for SARS-CoV-2 during follow-up examinations with 11 and four detections entailing stool samples and anal swabs, respectively, rather than respiratory samples. Juveniles were more accessible to "infection recurrence" than other age groups, with shorter time spans for RP RNA tests (an average of 8.8 days [6.0-9.0 days]), while the reverse was true for the middle-aged group (17.5 days on average [14.0-17.5 days]). Similar improvements in the imaging features of both RP and none RP (NRP) groups were observed. Negative antibody detections in patients 3 and 6 months after discharge were 14.2% and 25.0%, respectively. Cases evidencing negative antibodies were more common among juvenile patients (40% vs. 15.6%, p = 0.03) 6 months post-discharge.
Conclusions: 6.1% of 527 discharged patients showed RP status, which may be easier to be identified from stool samples than from other samples. Given the dropping rate of SARS-CoV-2 antibody, reinfection may happen especially in juvenile patients (age less than 18 years). Our findings have implications for the long-term management of recovered COVID-19 patients.
Keywords: COVID-19; antibody; discharged patients; follow-up; imaging features.
. 2021 Feb 1;S1201-9712(21)00075-8.
doi: 10.1016/j.ijid.2021.01.064. Online ahead of print.
The characteristics of 527 discharged COVID-19 patients undergoing long-term follow-up in China
Jintao Zhang[SUP] 1 [/SUP], Jiawei Xu[SUP] 1 [/SUP], Shengyu Zhou[SUP] 2 [/SUP], Chunting Wang[SUP] 3 [/SUP], Ximing Wang[SUP] 4 [/SUP], Wei Zhang[SUP] 5 [/SUP], Kang Ning[SUP] 6 [/SUP], Yun Pan[SUP] 1 [/SUP], Tian Liu[SUP] 2 [/SUP], Jiping Zhao[SUP] 2 [/SUP], Liang Dong[SUP] 7 [/SUP]
Affiliations
- PMID: 33540129
- DOI: 10.1016/j.ijid.2021.01.064
Abstract
Background: Almost a year after the outbreak of coronavirus disease 2019 (COVID-19), numerous hospitalized COVID-19 patients have recovered. However, little is known about the long-term follow-up (>2 months) of discharged patients.
Methods: We enrolled 527 discharged COVID-19 patients in a study from February 5 to March 11, 2020. These patients' basic characteristics, imaging features, nucleic acid detection results, and antibody levels were retrospectively reviewed.
Results: of the 527 discharged patients, 32 (6.1%) had re-detectable positive (RP) nucleic acid results for SARS-CoV-2 during follow-up examinations with 11 and four detections entailing stool samples and anal swabs, respectively, rather than respiratory samples. Juveniles were more accessible to "infection recurrence" than other age groups, with shorter time spans for RP RNA tests (an average of 8.8 days [6.0-9.0 days]), while the reverse was true for the middle-aged group (17.5 days on average [14.0-17.5 days]). Similar improvements in the imaging features of both RP and none RP (NRP) groups were observed. Negative antibody detections in patients 3 and 6 months after discharge were 14.2% and 25.0%, respectively. Cases evidencing negative antibodies were more common among juvenile patients (40% vs. 15.6%, p = 0.03) 6 months post-discharge.
Conclusions: 6.1% of 527 discharged patients showed RP status, which may be easier to be identified from stool samples than from other samples. Given the dropping rate of SARS-CoV-2 antibody, reinfection may happen especially in juvenile patients (age less than 18 years). Our findings have implications for the long-term management of recovered COVID-19 patients.
Keywords: COVID-19; antibody; discharged patients; follow-up; imaging features.