tetano
Editor, Senior Moderator
Int J Infect Dis
. 2020 Aug 3;S1201-9712(20)30514-2.
doi: 10.1016/j.ijid.2020.06.079. Online ahead of print.
The characteristics and predictive role of lymphocyte subsets in COVID-19 patients
Wenjing Zhang[SUP] 1 [/SUP], Lei Li[SUP] 2 [/SUP], Jihai Liu[SUP] 3 [/SUP], Li Chen[SUP] 4 [/SUP], Fangfang Zhou[SUP] 4 [/SUP], Ting Jin[SUP] 4 [/SUP], Lin Jiang[SUP] 4 [/SUP], Xiang Li[SUP] 4 [/SUP], Ming Yang[SUP] 5 [/SUP], Hongxiang Wang[SUP] 6 [/SUP]
Affiliations
Abstract
Objective: To investigate the characteristics and predictive roles of lymphocyte subsets in COVID-19 patients.
Method: We evaluated lymphocyte subsets and other clinical features of COVID-19 patients and analysed their potential impacts on COVID-19 outcomes.
Results: 1. Lymphocyte subset counts in the peripheral blood of patients with COVID-19 were significantly reduced, especially in patients with severe disease. 2. In patients with non-severe diseases, the time from symptom onset to hospital admission was positively correlated with total T cell counts. 3. Among COVID-19 patients who did not reach the composite endpoint, lymphocyte subset counts were higher than in patients who had reached the composite endpoint. 4. The Kaplan-Meier survival curves showed significant differences in COVID-19 patients, classified by the levels of total, CD8[SUP]+[/SUP] and CD4[SUP]+[/SUP] T cells at admission.
Conclusion: Our study shows that the total, CD8[SUP]+[/SUP] and CD4[SUP]+[/SUP] T cell counts in patients with COVID-19 were significantly reduced, especially in patients with severe disease. T lymphocyte subsets were significantly associated with a higher occurrence of composite endpoint events. These subsets may help identify patients with a high risk of composite endpoint events.
Keywords: coronavirus disease 2019; lymphocyte subsets; immune parameters; pneumonia.
. 2020 Aug 3;S1201-9712(20)30514-2.
doi: 10.1016/j.ijid.2020.06.079. Online ahead of print.
The characteristics and predictive role of lymphocyte subsets in COVID-19 patients
Wenjing Zhang[SUP] 1 [/SUP], Lei Li[SUP] 2 [/SUP], Jihai Liu[SUP] 3 [/SUP], Li Chen[SUP] 4 [/SUP], Fangfang Zhou[SUP] 4 [/SUP], Ting Jin[SUP] 4 [/SUP], Lin Jiang[SUP] 4 [/SUP], Xiang Li[SUP] 4 [/SUP], Ming Yang[SUP] 5 [/SUP], Hongxiang Wang[SUP] 6 [/SUP]
Affiliations
- PMID: 32758688
- DOI: 10.1016/j.ijid.2020.06.079
Abstract
Objective: To investigate the characteristics and predictive roles of lymphocyte subsets in COVID-19 patients.
Method: We evaluated lymphocyte subsets and other clinical features of COVID-19 patients and analysed their potential impacts on COVID-19 outcomes.
Results: 1. Lymphocyte subset counts in the peripheral blood of patients with COVID-19 were significantly reduced, especially in patients with severe disease. 2. In patients with non-severe diseases, the time from symptom onset to hospital admission was positively correlated with total T cell counts. 3. Among COVID-19 patients who did not reach the composite endpoint, lymphocyte subset counts were higher than in patients who had reached the composite endpoint. 4. The Kaplan-Meier survival curves showed significant differences in COVID-19 patients, classified by the levels of total, CD8[SUP]+[/SUP] and CD4[SUP]+[/SUP] T cells at admission.
Conclusion: Our study shows that the total, CD8[SUP]+[/SUP] and CD4[SUP]+[/SUP] T cell counts in patients with COVID-19 were significantly reduced, especially in patients with severe disease. T lymphocyte subsets were significantly associated with a higher occurrence of composite endpoint events. These subsets may help identify patients with a high risk of composite endpoint events.
Keywords: coronavirus disease 2019; lymphocyte subsets; immune parameters; pneumonia.