tetano
Editor, Senior Moderator
Int J Infect Dis
. 2020 Sep 22;S1201-9712(20)32133-0.
doi: 10.1016/j.ijid.2020.09.1417. Online ahead of print.
Temporal and age distributions of SARS-CoV-2 and other coronaviruses, Southeastern France
Philippe Colson[SUP] 1 [/SUP], Vera Esteves-Vieira[SUP] 2 [/SUP], Audrey Giraud-Gatineau[SUP] 3 [/SUP], Christine Zandotti[SUP] 2 [/SUP], V?ronique Filosa[SUP] 2 [/SUP], Herv? Chaudet[SUP] 3 [/SUP], Jean-Christophe Lagier[SUP] 1 [/SUP], Didier Raoult[SUP] 4 [/SUP]
Affiliations
Abstract
Objectives: The SARS-CoV-2 epidemic presents a poorly understood epidemiological cycle. We aimed to compare the age and weekly distribution of the five human coronaviruses, including SARS-CoV-2 that circulated in southeastern France.
Methods: We analyzed all available diagnoses of respiratory viruses including SARS-CoV-2 performed between 09/2013 and 05/2020 at University Hospital Institute M?diterran?e Infection in Marseille, Southeastern France.
Results: For SARS-CoV-2, positive children <15 years of age represented 3.4% (228/6,735) of all positive cases, which is significantly less than for endemic coronaviruses (46.1%; 533/1,156; p < 0.001). Among 10,026 patients tested for SARS-CoV-2 and endemic coronaviruses in 2020, children <15 years represented a significantly lower proportion of all positive cases for SARS-CoV-2 than for endemic coronaviruses [2.2% (24/1,067) vs 33.5% (149/445), respectively; p < 0.001]. Epidemic curves for endemic coronaviruses and SARS-CoV-2 in 91,722 patients showed comparable bell-shaped distributions with a slight time lag. In contrast, age distribution of endemic coronaviruses and 14 other respiratory viruses differed very significantly compared to that of SARS-CoV2, which was the only virus to spare children.
Conclusions: Thus, we observed for SARS-CoV-2 a temporal distribution resembling that of endemic coronaviruses and an age distribution that spares the youngest subjects who are those the most exposed to endemic coronaviruses.
Keywords: SARS-CoV-2; Southeastern France; age; children; cross-immunity; endemic coronavirus.
. 2020 Sep 22;S1201-9712(20)32133-0.
doi: 10.1016/j.ijid.2020.09.1417. Online ahead of print.
Temporal and age distributions of SARS-CoV-2 and other coronaviruses, Southeastern France
Philippe Colson[SUP] 1 [/SUP], Vera Esteves-Vieira[SUP] 2 [/SUP], Audrey Giraud-Gatineau[SUP] 3 [/SUP], Christine Zandotti[SUP] 2 [/SUP], V?ronique Filosa[SUP] 2 [/SUP], Herv? Chaudet[SUP] 3 [/SUP], Jean-Christophe Lagier[SUP] 1 [/SUP], Didier Raoult[SUP] 4 [/SUP]
Affiliations
- PMID: 32976991
- DOI: 10.1016/j.ijid.2020.09.1417
Abstract
Objectives: The SARS-CoV-2 epidemic presents a poorly understood epidemiological cycle. We aimed to compare the age and weekly distribution of the five human coronaviruses, including SARS-CoV-2 that circulated in southeastern France.
Methods: We analyzed all available diagnoses of respiratory viruses including SARS-CoV-2 performed between 09/2013 and 05/2020 at University Hospital Institute M?diterran?e Infection in Marseille, Southeastern France.
Results: For SARS-CoV-2, positive children <15 years of age represented 3.4% (228/6,735) of all positive cases, which is significantly less than for endemic coronaviruses (46.1%; 533/1,156; p < 0.001). Among 10,026 patients tested for SARS-CoV-2 and endemic coronaviruses in 2020, children <15 years represented a significantly lower proportion of all positive cases for SARS-CoV-2 than for endemic coronaviruses [2.2% (24/1,067) vs 33.5% (149/445), respectively; p < 0.001]. Epidemic curves for endemic coronaviruses and SARS-CoV-2 in 91,722 patients showed comparable bell-shaped distributions with a slight time lag. In contrast, age distribution of endemic coronaviruses and 14 other respiratory viruses differed very significantly compared to that of SARS-CoV2, which was the only virus to spare children.
Conclusions: Thus, we observed for SARS-CoV-2 a temporal distribution resembling that of endemic coronaviruses and an age distribution that spares the youngest subjects who are those the most exposed to endemic coronaviruses.
Keywords: SARS-CoV-2; Southeastern France; age; children; cross-immunity; endemic coronavirus.