tetano
Editor, Senior Moderator
Int J Infect Dis
. 2020 Nov 20;S1201-9712(20)32475-9.
doi: 10.1016/j.ijid.2020.11.163. Online ahead of print.
Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis
Boyan K Tsankov[SUP] 1 [/SUP], Joannie M Allaire[SUP] 2 [/SUP], Michael A Irvine[SUP] 3 [/SUP], Alison A Lopez[SUP] 4 [/SUP], Laura J Sauv?[SUP] 5 [/SUP], Bruce A Vallance[SUP] 6 [/SUP], Kevan Jacobson[SUP] 7 [/SUP]
Affiliations
Abstract
Objective: There is limited information on the severity of COVID-19 infection in children with comorbidities. We investigated the effects of pediatric comorbidities on COVID-19 severity by means of a systematic review and meta-analysis of published literature.
Methods: PubMed, Embase, and Medline databases were searched for publications on pediatric COVID-19 infections published January 1[SUP]st[/SUP] to October 5[SUP]th[/SUP], 2020. Articles describing at least one child with and without comorbidities, COVID-19 infection, and reported outcomes, were included.
Results: 42 studies containing 275,661 children without comorbidities and 9,353 children with comorbidities were included. Severe COVID-19 was present in 5.1% of children with comorbidities, and in 0.2% without comorbidities. Random-effects analysis revealed a higher risk of severe COVID-19 among children with comorbidities than for healthy children; relative risk ratio 1.79 (95% CI 1.27 - 2.51;I[SUP]2[/SUP] = 94%). Children with underlying conditions also had a higher risk of COVID-19-associated mortality; relative risk ratio 2.81 (95% CI 1.31 - 6.02; I[SUP]2[/SUP] = 82%). Children with obesity had a relative risk ratio of 2.87 (95% CI 1.16 - 7.07 I[SUP]2[/SUP] = 36%).
Conclusions: Children with comorbidities have a higher risk of severe COVID-19 and associated mortality than children without underlying disease. Additional studies are required to further evaluate this relationship.
Keywords: COVID-19; Comorbidity; Coronavirus; Meta-Analysis; Pediatrics.
. 2020 Nov 20;S1201-9712(20)32475-9.
doi: 10.1016/j.ijid.2020.11.163. Online ahead of print.
Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis
Boyan K Tsankov[SUP] 1 [/SUP], Joannie M Allaire[SUP] 2 [/SUP], Michael A Irvine[SUP] 3 [/SUP], Alison A Lopez[SUP] 4 [/SUP], Laura J Sauv?[SUP] 5 [/SUP], Bruce A Vallance[SUP] 6 [/SUP], Kevan Jacobson[SUP] 7 [/SUP]
Affiliations
- PMID: 33227520
- DOI: 10.1016/j.ijid.2020.11.163
Abstract
Objective: There is limited information on the severity of COVID-19 infection in children with comorbidities. We investigated the effects of pediatric comorbidities on COVID-19 severity by means of a systematic review and meta-analysis of published literature.
Methods: PubMed, Embase, and Medline databases were searched for publications on pediatric COVID-19 infections published January 1[SUP]st[/SUP] to October 5[SUP]th[/SUP], 2020. Articles describing at least one child with and without comorbidities, COVID-19 infection, and reported outcomes, were included.
Results: 42 studies containing 275,661 children without comorbidities and 9,353 children with comorbidities were included. Severe COVID-19 was present in 5.1% of children with comorbidities, and in 0.2% without comorbidities. Random-effects analysis revealed a higher risk of severe COVID-19 among children with comorbidities than for healthy children; relative risk ratio 1.79 (95% CI 1.27 - 2.51;I[SUP]2[/SUP] = 94%). Children with underlying conditions also had a higher risk of COVID-19-associated mortality; relative risk ratio 2.81 (95% CI 1.31 - 6.02; I[SUP]2[/SUP] = 82%). Children with obesity had a relative risk ratio of 2.87 (95% CI 1.16 - 7.07 I[SUP]2[/SUP] = 36%).
Conclusions: Children with comorbidities have a higher risk of severe COVID-19 and associated mortality than children without underlying disease. Additional studies are required to further evaluate this relationship.
Keywords: COVID-19; Comorbidity; Coronavirus; Meta-Analysis; Pediatrics.