tetano
Editor, Senior Moderator
Int J Infect Dis
. 2020 Dec 10;S1201-9712(20)32534-0.
doi: 10.1016/j.ijid.2020.12.011. Online ahead of print.
Retrospective study identifies infection related risk factors in close contacts during COVID-19 epidemic
Peipei Hu[SUP] 1 [/SUP], Mengmeng Ma[SUP] 2 [/SUP], Qinlong Jing[SUP] 2 [/SUP], Yu Ma[SUP] 2 [/SUP], Lin Gan[SUP] 1 [/SUP], Yan Chen[SUP] 3 [/SUP], Jundi Liu[SUP] 1 [/SUP], Dahu Wang[SUP] 2 [/SUP], Zhoubin Zhang[SUP] 4 [/SUP], Dingmei Zhang[SUP] 5 [/SUP]
Affiliations
Abstract
Objectives: This study aimed to compare the risk of infection of children with that of adults and explore risk factors of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by following up close contacts of COVID-19 patients.
Method: The retrospective cohort study was performed among close contacts of index cases diagnosed with COVID-19 in Guangzhou, China. Demographic characteristics, clinical symptoms and exposure information were extracted. Logistic regression analysis was employed to explore the risk factors. The restricted cubic spline was conducted to examine to the dose-response relationship between age and SARS-CoV-2 infection.
Results: The secondary attack rate (SAR) was 4.4% in 1,344 close contacts. The group of household contacts (17.2%) had the highest SAR. The rare-frequency contact (p < 0.001) and moderate-frequency contact (p < 0.001) were associated with lower risk of infection. Exposure to index cases with dry cough symptoms was associated with infection in close contacts (p = 0.004). Compared with children, adults had a significantly increased risk of infection (p = 0.014). There is a linear positive correlation between age and infection (p = 0.001).
Conclusions: Children are probably less susceptible to COVID-19. Close contacts with frequent contact with patients and those exposed to patients with cough symptoms are associated with an increased risk of infection.
Keywords: COVID-19; Children; Household contact; Secondary attack rate.
. 2020 Dec 10;S1201-9712(20)32534-0.
doi: 10.1016/j.ijid.2020.12.011. Online ahead of print.
Retrospective study identifies infection related risk factors in close contacts during COVID-19 epidemic
Peipei Hu[SUP] 1 [/SUP], Mengmeng Ma[SUP] 2 [/SUP], Qinlong Jing[SUP] 2 [/SUP], Yu Ma[SUP] 2 [/SUP], Lin Gan[SUP] 1 [/SUP], Yan Chen[SUP] 3 [/SUP], Jundi Liu[SUP] 1 [/SUP], Dahu Wang[SUP] 2 [/SUP], Zhoubin Zhang[SUP] 4 [/SUP], Dingmei Zhang[SUP] 5 [/SUP]
Affiliations
- PMID: 33310026
- DOI: 10.1016/j.ijid.2020.12.011
Abstract
Objectives: This study aimed to compare the risk of infection of children with that of adults and explore risk factors of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by following up close contacts of COVID-19 patients.
Method: The retrospective cohort study was performed among close contacts of index cases diagnosed with COVID-19 in Guangzhou, China. Demographic characteristics, clinical symptoms and exposure information were extracted. Logistic regression analysis was employed to explore the risk factors. The restricted cubic spline was conducted to examine to the dose-response relationship between age and SARS-CoV-2 infection.
Results: The secondary attack rate (SAR) was 4.4% in 1,344 close contacts. The group of household contacts (17.2%) had the highest SAR. The rare-frequency contact (p < 0.001) and moderate-frequency contact (p < 0.001) were associated with lower risk of infection. Exposure to index cases with dry cough symptoms was associated with infection in close contacts (p = 0.004). Compared with children, adults had a significantly increased risk of infection (p = 0.014). There is a linear positive correlation between age and infection (p = 0.001).
Conclusions: Children are probably less susceptible to COVID-19. Close contacts with frequent contact with patients and those exposed to patients with cough symptoms are associated with an increased risk of infection.
Keywords: COVID-19; Children; Household contact; Secondary attack rate.