tetano
Editor, Senior Moderator
Int J Infect Dis
. 2021 Feb 23;S1201-9712(21)00171-5.
doi: 10.1016/j.ijid.2021.02.085. Online ahead of print.
Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1)
Martin Dugas[SUP] 1 [/SUP], Tanja Grote-Westrick[SUP] 2 [/SUP], Richard Vollenberg[SUP] 3 [/SUP], Eva Lorentzen[SUP] 2 [/SUP], Tobias Brix[SUP] 4 [/SUP], Hartmut Schmidt[SUP] 3 [/SUP], Phil-Robin Tepasse[SUP] 3 [/SUP], Joachim K?hn[SUP] 2 [/SUP]
Affiliations
Abstract
The clinical course of COVID-19 is very heterogeneous: Most infected individuals can be managed in an outpatient setting, but a substantial proportion of patients requires intensive care, resulting in a high rate of fatalities. We performed a biomarker study to assess the impact of prior infections with seasonal coronaviruses on COVID-19 severity. 60 patients with confirmed COVID-19 infections were included (age 30 - 82 years; 52 males, 8 females): 19 inpatients with critical disease, 16 inpatients with severe or moderate disease and 25 outpatients. Patients with critical disease had significantly lower levels of anti-HCoV OC43-NP (p = 0.016) and HCoV HKU1-NP (p = 0.023) antibodies at the first encounter compared to other COVID-19 patients. Our results indicate that prior infections with seasonal coronaviruses might protect against a severe course of disease.
Keywords: COVID-19; HKU1; OC43; seasonal coronaviruses.
. 2021 Feb 23;S1201-9712(21)00171-5.
doi: 10.1016/j.ijid.2021.02.085. Online ahead of print.
Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1)
Martin Dugas[SUP] 1 [/SUP], Tanja Grote-Westrick[SUP] 2 [/SUP], Richard Vollenberg[SUP] 3 [/SUP], Eva Lorentzen[SUP] 2 [/SUP], Tobias Brix[SUP] 4 [/SUP], Hartmut Schmidt[SUP] 3 [/SUP], Phil-Robin Tepasse[SUP] 3 [/SUP], Joachim K?hn[SUP] 2 [/SUP]
Affiliations
- PMID: 33636357
- PMCID: PMC7901274
- DOI: 10.1016/j.ijid.2021.02.085
Abstract
The clinical course of COVID-19 is very heterogeneous: Most infected individuals can be managed in an outpatient setting, but a substantial proportion of patients requires intensive care, resulting in a high rate of fatalities. We performed a biomarker study to assess the impact of prior infections with seasonal coronaviruses on COVID-19 severity. 60 patients with confirmed COVID-19 infections were included (age 30 - 82 years; 52 males, 8 females): 19 inpatients with critical disease, 16 inpatients with severe or moderate disease and 25 outpatients. Patients with critical disease had significantly lower levels of anti-HCoV OC43-NP (p = 0.016) and HCoV HKU1-NP (p = 0.023) antibodies at the first encounter compared to other COVID-19 patients. Our results indicate that prior infections with seasonal coronaviruses might protect against a severe course of disease.
Keywords: COVID-19; HKU1; OC43; seasonal coronaviruses.