tetano
Editor, Senior Moderator
Int J Infect Dis
. 2022 Feb 12;S1201-9712(22)00078-9.
doi: 10.1016/j.ijid.2022.02.003. Online ahead of print.
Independent risk factors of COVID-19 pneumonia in vaccinated Mexican adults
Efrén Murillo-Zamora[SUP] 1 [/SUP], Ramón Alberto Sánchez-Piña[SUP] 2 [/SUP], Xóchitl Trujillo[SUP] 3 [/SUP], Miguel Huerta[SUP] 3 [/SUP], Mónica Ríos-Silva[SUP] 4 [/SUP], Oliver Mendoza-Cano[SUP] 5 [/SUP]
Affiliations
Abstract
Objective: To evaluate host factors associated with the risk of coronavirus disease 2019 (COVID-19) pneumonia in vaccinated adults.
Methods: A cohort study was conducted in Mexico, and data from 1,607 adults with confirmed illness, with a positive history of COVID-19 vaccination, were analyzed. Risk ratios (RR) and 95% confidence intervals (CI) were computed as a measure of the significance of the associations between putative risk factors and the prevalence of COVID-19 pneumonia in vaccinated subjects.
Results: The overall risk of pneumonia was 1.98 per 1,000 person-days. In the multiple regression analysis, older subjects and those with a history of smoking (current), obesity, and type 2 diabetes mellitus were at increased risk of pneumonia.
Conclusions: Our results suggest that the effectiveness of COVID-19 vaccines may be reduced in a subset of adults who are elderly, or are smokers, obese or have type 2 diabetes mellitus.
Keywords: COVID-19; Diabetes Mellitus, Type 2; Obesity; Pneumonia; Smoking; Vaccination.
. 2022 Feb 12;S1201-9712(22)00078-9.
doi: 10.1016/j.ijid.2022.02.003. Online ahead of print.
Independent risk factors of COVID-19 pneumonia in vaccinated Mexican adults
Efrén Murillo-Zamora[SUP] 1 [/SUP], Ramón Alberto Sánchez-Piña[SUP] 2 [/SUP], Xóchitl Trujillo[SUP] 3 [/SUP], Miguel Huerta[SUP] 3 [/SUP], Mónica Ríos-Silva[SUP] 4 [/SUP], Oliver Mendoza-Cano[SUP] 5 [/SUP]
Affiliations
- PMID: 35167967
- DOI: 10.1016/j.ijid.2022.02.003
Abstract
Objective: To evaluate host factors associated with the risk of coronavirus disease 2019 (COVID-19) pneumonia in vaccinated adults.
Methods: A cohort study was conducted in Mexico, and data from 1,607 adults with confirmed illness, with a positive history of COVID-19 vaccination, were analyzed. Risk ratios (RR) and 95% confidence intervals (CI) were computed as a measure of the significance of the associations between putative risk factors and the prevalence of COVID-19 pneumonia in vaccinated subjects.
Results: The overall risk of pneumonia was 1.98 per 1,000 person-days. In the multiple regression analysis, older subjects and those with a history of smoking (current), obesity, and type 2 diabetes mellitus were at increased risk of pneumonia.
Conclusions: Our results suggest that the effectiveness of COVID-19 vaccines may be reduced in a subset of adults who are elderly, or are smokers, obese or have type 2 diabetes mellitus.
Keywords: COVID-19; Diabetes Mellitus, Type 2; Obesity; Pneumonia; Smoking; Vaccination.