tetano
Editor, Senior Moderator
Int J Infect Dis
. 2024 Apr 30:107067.
doi: 10.1016/j.ijid.2024.107067. Online ahead of print. Gene variants rs5182, rs2074192, and rs4343 in the Renin-Angiotensin-Aldosterone system are associated with symptom severity, higher odds of hospitalization, and death in COVID-19
M L Martinez-Fierro[SUP] 1 [/SUP], A Perez-Favila[SUP] 2 [/SUP], S M Zorrilla Alfaro[SUP] 2 [/SUP], S A Oropeza-de Lara[SUP] 2 [/SUP], I Garza-Veloz[SUP] 2 [/SUP], L S Hernandez-Marquez[SUP] 2 [/SUP], E F Gutierrez-Vela[SUP] 3 [/SUP], I Delgado-Enciso[SUP] 4 [/SUP], I P Rodriguez-Sanchez[SUP] 5 [/SUP]
Affiliations
Objective: To analyze the gene variants of the renin-angiotensin-aldosterone system (RAAS) and determine their association with the severity and outcome of coronavirus disease 19 (COVID-19).
Methods: A total of 104 patients were included in the study: 34 asymptomatic patients with COVID-19 as controls and 70 symptomatic patients as cases. The genetic variants ACE rs4343, ACE2 rs2074192, AGTR1 rs5182, and AGT rs4762, were identified using TaqMan genotyping tests.
Results: Patients with the T/T genotype of AGTR1 rs5182 have a higher probability of developing symptomatic COVID-19 (OR= 12.25; 95% CI: 1.34-111.9; p ≤ 0.001) and a higher risk of hospitalization because of disease (OR= 14.00; 95% CI: 1.53-128.49; p = 0.012). The haplotype CTG (AGTR1 rs5182, ACE2 rs2074192, ACE rs4343) decreased the odds of death related to COVID-19 among the study population (OR= 0.03; 95% CI: 0.0-0.06; p = 0.026).
Conclusion: The T/T genotype of the AGTR1 rs5182 variant increased the probability of symptomatic COVID-19 and hospitalization, whereas that, the haplotype CTG (consisting of AGTR1 rs5182, ACE2 rs2074192, and ACE rs4343) decreased the odds of death related to COVID-19 by 97% among the hospitalized patients with COVID-19. These results support the participation of RAAS gene variants as modifiers of the severity of symptoms associated with SARS-CoV-2 infection and the outcome of COVID-19.
Keywords: ACE; ACE2; AGTR1; COVID-19; RAAS; gene-variants.
. 2024 Apr 30:107067.
doi: 10.1016/j.ijid.2024.107067. Online ahead of print. Gene variants rs5182, rs2074192, and rs4343 in the Renin-Angiotensin-Aldosterone system are associated with symptom severity, higher odds of hospitalization, and death in COVID-19
M L Martinez-Fierro[SUP] 1 [/SUP], A Perez-Favila[SUP] 2 [/SUP], S M Zorrilla Alfaro[SUP] 2 [/SUP], S A Oropeza-de Lara[SUP] 2 [/SUP], I Garza-Veloz[SUP] 2 [/SUP], L S Hernandez-Marquez[SUP] 2 [/SUP], E F Gutierrez-Vela[SUP] 3 [/SUP], I Delgado-Enciso[SUP] 4 [/SUP], I P Rodriguez-Sanchez[SUP] 5 [/SUP]
Affiliations
- PMID: 38697603
- DOI: 10.1016/j.ijid.2024.107067
Objective: To analyze the gene variants of the renin-angiotensin-aldosterone system (RAAS) and determine their association with the severity and outcome of coronavirus disease 19 (COVID-19).
Methods: A total of 104 patients were included in the study: 34 asymptomatic patients with COVID-19 as controls and 70 symptomatic patients as cases. The genetic variants ACE rs4343, ACE2 rs2074192, AGTR1 rs5182, and AGT rs4762, were identified using TaqMan genotyping tests.
Results: Patients with the T/T genotype of AGTR1 rs5182 have a higher probability of developing symptomatic COVID-19 (OR= 12.25; 95% CI: 1.34-111.9; p ≤ 0.001) and a higher risk of hospitalization because of disease (OR= 14.00; 95% CI: 1.53-128.49; p = 0.012). The haplotype CTG (AGTR1 rs5182, ACE2 rs2074192, ACE rs4343) decreased the odds of death related to COVID-19 among the study population (OR= 0.03; 95% CI: 0.0-0.06; p = 0.026).
Conclusion: The T/T genotype of the AGTR1 rs5182 variant increased the probability of symptomatic COVID-19 and hospitalization, whereas that, the haplotype CTG (consisting of AGTR1 rs5182, ACE2 rs2074192, and ACE rs4343) decreased the odds of death related to COVID-19 by 97% among the hospitalized patients with COVID-19. These results support the participation of RAAS gene variants as modifiers of the severity of symptoms associated with SARS-CoV-2 infection and the outcome of COVID-19.
Keywords: ACE; ACE2; AGTR1; COVID-19; RAAS; gene-variants.