tetano
Editor, Senior Moderator
Int J Infect Dis
. 2023 Jan 29;S1201-9712(23)00031-0.
doi: 10.1016/j.ijid.2023.01.030. Online ahead of print.
Epidemiological, Clinical and Household Transmission Characteristics of Children and Adolescents Infected with SARS-CoV-2 Omicron Variant in Shanghai, China: a Retrospective Multicenter Observational Study
Yazun Liu[SUP] 1 [/SUP], Lan Xu[SUP] 2 [/SUP], Xiang Piao[SUP] 1 [/SUP], Han Li[SUP] 1 [/SUP], Li Shi[SUP] 3 [/SUP], Yue Huang[SUP] 2 [/SUP], Huan Zhou[SUP] 1 [/SUP], Yan Yang[SUP] 1 [/SUP], Xiao Liu[SUP] 1 [/SUP], Mingyun Wu[SUP] 1 [/SUP], Yuanyuan He[SUP] 4 [/SUP], Yong Yin[SUP] 5 [/SUP], Libo Wang[SUP] 4 [/SUP], Jian Yu[SUP] 4 [/SUP], Wenhao Zhou[SUP] 4 [/SUP], Junhua Zheng[SUP] 6 [/SUP], Victor W Zhong[SUP] 7 [/SUP], Zheng Xue[SUP] 1 [/SUP], Liwei Zhong[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: To describe the epidemiological, clinical, and household transmission characteristics of pediatric coronavirus disease 2019 (COVID-19) cases in Shanghai, China.
Methods: Pediatric patients with COVID-19 hospitalized in Shanghai from March-May 2022 were enrolled in this retrospective multicenter cohort study. The symptoms and the risk factors associated with disease severity were analyzed.
Results: In total, 2,620 cases (age range, 24 days-17 years) were enrolled in this study. Of these, 1,011 (38.6%) were asymptomatic, whereas 1,415 (54.0%), 190 (7.3%), and 4 (0.2%) patients developed mild, moderate, and severe illnesses respectively. Household infection rate was negatively correlated with household vaccination coverage. Children 0-3 years, those unvaccinated, with underlying diseases, and overweight/obese children, had a higher risk of developing moderate to severe disease than children 12-17 years, those vaccinated, without any underlying disease, and with normal weight, respectively (all p<0.05). Prolonged duration of viral shedding was associated with disease severity, presence of underlying diseases, vaccination status, and younger age (all p<0.05).
Conclusions: Children younger than 3 years old who were not eligible for vaccination had a high risk of developing moderate to severe COVID-19 with a prolonged duration of viral shedding. Vaccination could protect children from COVID-19 at the household level.
Keywords: Epidemiology; Household Transmission; Omicron; Pediatrics; SARS-CoV-2.
. 2023 Jan 29;S1201-9712(23)00031-0.
doi: 10.1016/j.ijid.2023.01.030. Online ahead of print.
Epidemiological, Clinical and Household Transmission Characteristics of Children and Adolescents Infected with SARS-CoV-2 Omicron Variant in Shanghai, China: a Retrospective Multicenter Observational Study
Yazun Liu[SUP] 1 [/SUP], Lan Xu[SUP] 2 [/SUP], Xiang Piao[SUP] 1 [/SUP], Han Li[SUP] 1 [/SUP], Li Shi[SUP] 3 [/SUP], Yue Huang[SUP] 2 [/SUP], Huan Zhou[SUP] 1 [/SUP], Yan Yang[SUP] 1 [/SUP], Xiao Liu[SUP] 1 [/SUP], Mingyun Wu[SUP] 1 [/SUP], Yuanyuan He[SUP] 4 [/SUP], Yong Yin[SUP] 5 [/SUP], Libo Wang[SUP] 4 [/SUP], Jian Yu[SUP] 4 [/SUP], Wenhao Zhou[SUP] 4 [/SUP], Junhua Zheng[SUP] 6 [/SUP], Victor W Zhong[SUP] 7 [/SUP], Zheng Xue[SUP] 1 [/SUP], Liwei Zhong[SUP] 1 [/SUP]
Affiliations
- PMID: 36724865
- DOI: 10.1016/j.ijid.2023.01.030
Abstract
Objective: To describe the epidemiological, clinical, and household transmission characteristics of pediatric coronavirus disease 2019 (COVID-19) cases in Shanghai, China.
Methods: Pediatric patients with COVID-19 hospitalized in Shanghai from March-May 2022 were enrolled in this retrospective multicenter cohort study. The symptoms and the risk factors associated with disease severity were analyzed.
Results: In total, 2,620 cases (age range, 24 days-17 years) were enrolled in this study. Of these, 1,011 (38.6%) were asymptomatic, whereas 1,415 (54.0%), 190 (7.3%), and 4 (0.2%) patients developed mild, moderate, and severe illnesses respectively. Household infection rate was negatively correlated with household vaccination coverage. Children 0-3 years, those unvaccinated, with underlying diseases, and overweight/obese children, had a higher risk of developing moderate to severe disease than children 12-17 years, those vaccinated, without any underlying disease, and with normal weight, respectively (all p<0.05). Prolonged duration of viral shedding was associated with disease severity, presence of underlying diseases, vaccination status, and younger age (all p<0.05).
Conclusions: Children younger than 3 years old who were not eligible for vaccination had a high risk of developing moderate to severe COVID-19 with a prolonged duration of viral shedding. Vaccination could protect children from COVID-19 at the household level.
Keywords: Epidemiology; Household Transmission; Omicron; Pediatrics; SARS-CoV-2.