tetano
Editor, Senior Moderator
Int J Infect Dis
. 2020 Jul 24;S1201-9712(20)30576-2.
doi: 10.1016/j.ijid.2020.07.032. Online ahead of print.
Effectiveness of Trivalent Inactivated Influenza Vaccines in Children during 2017-2018 Season in Korea: Comparison of Test-Negative Analysis by Rapid and RT-PCR Influenza Tests
Young Joo Sohn[SUP] 1 [/SUP], Jae Hong Choi[SUP] 2 [/SUP], Youn Young Choi[SUP] 1 [/SUP], Young June Choe[SUP] 3 [/SUP], Kyungmin Kim[SUP] 4 [/SUP], Ye Kyung Kim[SUP] 1 [/SUP], Bin Ahn[SUP] 1 [/SUP], Seung Ha Song[SUP] 1 [/SUP], Mi Seon Han[SUP] 1 [/SUP], Ji Young Park[SUP] 4 [/SUP], Joon Kee Lee[SUP] 5 [/SUP], Eun Hwa Choi[SUP] 6 [/SUP]
Affiliations
Abstract
Objectives: In Korea, the National Immunization Program provided trivalent inactivated influenza vaccines (IIV3) to all children aged 6 - 59 months during the 2017-2018 season. In this study, we aimed to evaluate the vaccine effectiveness (VE) of IIV3 in children during the 2017-2018 season.
Methods: Children aged 6 -59 months who were tested for influenza for their acute respiratory illness were included in four hospitals during the 2017-2018 influenza season. We estimated the VE of IIV3 by test-negative case-control design based on the rapid influenza diagnostic test (RIDT) or reverse transcription polymerase chain reaction (RT-PCR) test results.
Results: A total of 4,738 children were included in this study. The number of laboratory-confirmed influenza cases was 845 (17.8%), and there were 478 cases of influenza A, 362 cases of influenza B. The adjusted VE based on RT-PCR was 53.4% (95% CI, 25.3-70.5) against any influenza, 68.8% (95% CI, 38.7-84.1) against influenza A, and 29.7% (95% CI, -35.1-61.8) for influenza B. The adjusted VE based on RIDT was 14.8% (95% CI, -4.4-30.0) against any influenza, 24.2% (95% CI, 3.1-40.2) against influenza A, and -5.1% (95% CI, -42.6-21.4) against influenza B. Age-specific VE based on RT-PCR against any influenza was 44.1% (95% CI, -0.2-67.8) in children aged 6 months to 2 years and 59.3% (95% CI, 8.8-81.9) in children aged 3 to 5 years.
Conclusion: Our results suggest moderate protection (53.4%) of IIV3 against RT-PCR laboratory-confirmed influenza in children in the 2017-2018 influenza season. However, the RIDT hampered the validity to assess VE during influenza season. Caution is needed when interpreting RIDT-based test negative design influenza VE study.
Keywords: Children; Inactivated influenza vaccine; Seasonal influenza; Vaccine effectiveness.
. 2020 Jul 24;S1201-9712(20)30576-2.
doi: 10.1016/j.ijid.2020.07.032. Online ahead of print.
Effectiveness of Trivalent Inactivated Influenza Vaccines in Children during 2017-2018 Season in Korea: Comparison of Test-Negative Analysis by Rapid and RT-PCR Influenza Tests
Young Joo Sohn[SUP] 1 [/SUP], Jae Hong Choi[SUP] 2 [/SUP], Youn Young Choi[SUP] 1 [/SUP], Young June Choe[SUP] 3 [/SUP], Kyungmin Kim[SUP] 4 [/SUP], Ye Kyung Kim[SUP] 1 [/SUP], Bin Ahn[SUP] 1 [/SUP], Seung Ha Song[SUP] 1 [/SUP], Mi Seon Han[SUP] 1 [/SUP], Ji Young Park[SUP] 4 [/SUP], Joon Kee Lee[SUP] 5 [/SUP], Eun Hwa Choi[SUP] 6 [/SUP]
Affiliations
- PMID: 32717398
- DOI: 10.1016/j.ijid.2020.07.032
Abstract
Objectives: In Korea, the National Immunization Program provided trivalent inactivated influenza vaccines (IIV3) to all children aged 6 - 59 months during the 2017-2018 season. In this study, we aimed to evaluate the vaccine effectiveness (VE) of IIV3 in children during the 2017-2018 season.
Methods: Children aged 6 -59 months who were tested for influenza for their acute respiratory illness were included in four hospitals during the 2017-2018 influenza season. We estimated the VE of IIV3 by test-negative case-control design based on the rapid influenza diagnostic test (RIDT) or reverse transcription polymerase chain reaction (RT-PCR) test results.
Results: A total of 4,738 children were included in this study. The number of laboratory-confirmed influenza cases was 845 (17.8%), and there were 478 cases of influenza A, 362 cases of influenza B. The adjusted VE based on RT-PCR was 53.4% (95% CI, 25.3-70.5) against any influenza, 68.8% (95% CI, 38.7-84.1) against influenza A, and 29.7% (95% CI, -35.1-61.8) for influenza B. The adjusted VE based on RIDT was 14.8% (95% CI, -4.4-30.0) against any influenza, 24.2% (95% CI, 3.1-40.2) against influenza A, and -5.1% (95% CI, -42.6-21.4) against influenza B. Age-specific VE based on RT-PCR against any influenza was 44.1% (95% CI, -0.2-67.8) in children aged 6 months to 2 years and 59.3% (95% CI, 8.8-81.9) in children aged 3 to 5 years.
Conclusion: Our results suggest moderate protection (53.4%) of IIV3 against RT-PCR laboratory-confirmed influenza in children in the 2017-2018 influenza season. However, the RIDT hampered the validity to assess VE during influenza season. Caution is needed when interpreting RIDT-based test negative design influenza VE study.
Keywords: Children; Inactivated influenza vaccine; Seasonal influenza; Vaccine effectiveness.