tetano
Editor, Senior Moderator
Int J Infect Dis
. 2020 Dec 14;S1201-9712(20)32551-0.
doi: 10.1016/j.ijid.2020.12.028. Online ahead of print.
Effectiveness of Neuraminidase Inhibitors to Prevent Mortality in Laboratory-Confirmed Avian Influenza A H7N9 Patients
Wei Cheng[SUP] 1 [/SUP], Anqi Pan[SUP] 2 [/SUP], Stephen L Rathbun[SUP] 2 [/SUP], Yang Ge[SUP] 2 [/SUP], Qian Xiao[SUP] 3 [/SUP], Leonardo Martinez[SUP] 4 [/SUP], Feng Ling[SUP] 1 [/SUP], Shelan Liu[SUP] 1 [/SUP], Xiaoxiao Wang[SUP] 1 [/SUP], Zhao Yu[SUP] 1 [/SUP], Mark H Ebell[SUP] 2 [/SUP], Changwei Li[SUP] 5 [/SUP], Andreas Handel[SUP] 6 [/SUP], Enfu Chen[SUP] 1 [/SUP], Ye Shen[SUP] 7 [/SUP]
Affiliations
Abstract
Objectives: Human infection with avian influenza virus A(H7N9) remains a big threat and has a great potential to cause a pandemic in the foreseeable future. Antiviral treatment using the neuraminidase inhibitors has been recommended to treat H7N9 patients as early as possible, while evidence-based research on its effectiveness for the specific H7N9 infection was lacking.
Methods: We reviewed data from all laboratory-confirmed avian influenza A H7N9 cases in Zhejiang province between 2013 and 2017 and fit time-dependent survival models to evaluate the effectiveness of neuraminidase inhibitors treatment as an intervention to reduce death risk.
Results: The result of our final model indicated that there is no significant association (Odds Ratio = 1.29, 95% Confidence Interval [0.78-2.15]) between time to neuraminidase inhibitors treatment and survivorship after controlling for both age and white cell count. Sensitivity analyses with multiple imputation for missing data concurred with the primary complete case analysis.
Conclusions: . We did not find an association between neuraminidase inhibitors treatment and survival benefit in H7N9 patients across various adjusted models and sensitivity analyses of missing data imputations.
Keywords: H7N9 infection; effectiveness; influenza; mortality; neuraminidase inhibitors.
. 2020 Dec 14;S1201-9712(20)32551-0.
doi: 10.1016/j.ijid.2020.12.028. Online ahead of print.
Effectiveness of Neuraminidase Inhibitors to Prevent Mortality in Laboratory-Confirmed Avian Influenza A H7N9 Patients
Wei Cheng[SUP] 1 [/SUP], Anqi Pan[SUP] 2 [/SUP], Stephen L Rathbun[SUP] 2 [/SUP], Yang Ge[SUP] 2 [/SUP], Qian Xiao[SUP] 3 [/SUP], Leonardo Martinez[SUP] 4 [/SUP], Feng Ling[SUP] 1 [/SUP], Shelan Liu[SUP] 1 [/SUP], Xiaoxiao Wang[SUP] 1 [/SUP], Zhao Yu[SUP] 1 [/SUP], Mark H Ebell[SUP] 2 [/SUP], Changwei Li[SUP] 5 [/SUP], Andreas Handel[SUP] 6 [/SUP], Enfu Chen[SUP] 1 [/SUP], Ye Shen[SUP] 7 [/SUP]
Affiliations
- PMID: 33333253
- DOI: 10.1016/j.ijid.2020.12.028
Abstract
Objectives: Human infection with avian influenza virus A(H7N9) remains a big threat and has a great potential to cause a pandemic in the foreseeable future. Antiviral treatment using the neuraminidase inhibitors has been recommended to treat H7N9 patients as early as possible, while evidence-based research on its effectiveness for the specific H7N9 infection was lacking.
Methods: We reviewed data from all laboratory-confirmed avian influenza A H7N9 cases in Zhejiang province between 2013 and 2017 and fit time-dependent survival models to evaluate the effectiveness of neuraminidase inhibitors treatment as an intervention to reduce death risk.
Results: The result of our final model indicated that there is no significant association (Odds Ratio = 1.29, 95% Confidence Interval [0.78-2.15]) between time to neuraminidase inhibitors treatment and survivorship after controlling for both age and white cell count. Sensitivity analyses with multiple imputation for missing data concurred with the primary complete case analysis.
Conclusions: . We did not find an association between neuraminidase inhibitors treatment and survival benefit in H7N9 patients across various adjusted models and sensitivity analyses of missing data imputations.
Keywords: H7N9 infection; effectiveness; influenza; mortality; neuraminidase inhibitors.