tetano
Editor, Senior Moderator
Int J Infect Dis. 2020 Apr 3. pii: S1201-9712(20)30198-3. doi: 10.1016/j.ijid.2020.03.065. [Epub ahead of print]
Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019.
Jin Y[SUP]1[/SUP], Wang M[SUP]1[/SUP], Zuo Z[SUP]1[/SUP], Fan C[SUP]2[/SUP], Ye F[SUP]3[/SUP], Cai Z[SUP]4[/SUP], Wang Y[SUP]1[/SUP], Cui H[SUP]1[/SUP], Pan K[SUP]1[/SUP], Xu A[SUP]5[/SUP].
Author information
Abstract
OBJECTIVE:
To investigate the diagnostic value of serological test and dynamitic variance of serum antibody in coronavirus disease 2019 (COVID-19).
METHODS:
We retrospectively included 43 patients with a laboratory-confirmed infection and 33 patients with suspected infection who were finally excluded. The IgM/IgG titer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was measured by chemiluminescence immunoassay analysis.
RESULTS:
Compared to molecular detection, the sensitivity of serum IgM and IgG antibodies to diagnose COVID-19 were 48.1% and 88.9%, and the specificity were 100% and 90.9%, respectively. In COVID-19 group, IgM positive rate almost increased first then decreased over time, however, IgG positive rate increased till 100% and was higher than IgM all the time. IgM positive rate and titer were not significantly different before and after viral negative. IgG positive rate was up to 90% and not significantly different before and after viral negative. However, the median titer of IgG after viral negative was twice than that before with significant difference.
CONCLUSION:
Viral serological test is an effective diagnostic means for SARS-CoV-2 infection. The positive rate and titer variance of IgG are higher than that of IgM in COVID-19.
Copyright ? 2020. Published by Elsevier Ltd.
KEYWORDS:
COVID-19; Immunoglobulin G; Immunoglobulin M; SARS-CoV-2; diagnosis; serological test
PMID:32251798DOI:10.1016/j.ijid.2020.03.065
Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019.
Jin Y[SUP]1[/SUP], Wang M[SUP]1[/SUP], Zuo Z[SUP]1[/SUP], Fan C[SUP]2[/SUP], Ye F[SUP]3[/SUP], Cai Z[SUP]4[/SUP], Wang Y[SUP]1[/SUP], Cui H[SUP]1[/SUP], Pan K[SUP]1[/SUP], Xu A[SUP]5[/SUP].
Author information
Abstract
OBJECTIVE:
To investigate the diagnostic value of serological test and dynamitic variance of serum antibody in coronavirus disease 2019 (COVID-19).
METHODS:
We retrospectively included 43 patients with a laboratory-confirmed infection and 33 patients with suspected infection who were finally excluded. The IgM/IgG titer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was measured by chemiluminescence immunoassay analysis.
RESULTS:
Compared to molecular detection, the sensitivity of serum IgM and IgG antibodies to diagnose COVID-19 were 48.1% and 88.9%, and the specificity were 100% and 90.9%, respectively. In COVID-19 group, IgM positive rate almost increased first then decreased over time, however, IgG positive rate increased till 100% and was higher than IgM all the time. IgM positive rate and titer were not significantly different before and after viral negative. IgG positive rate was up to 90% and not significantly different before and after viral negative. However, the median titer of IgG after viral negative was twice than that before with significant difference.
CONCLUSION:
Viral serological test is an effective diagnostic means for SARS-CoV-2 infection. The positive rate and titer variance of IgG are higher than that of IgM in COVID-19.
Copyright ? 2020. Published by Elsevier Ltd.
KEYWORDS:
COVID-19; Immunoglobulin G; Immunoglobulin M; SARS-CoV-2; diagnosis; serological test
PMID:32251798DOI:10.1016/j.ijid.2020.03.065