tetano
Editor, Senior Moderator
Int J Infect Dis
. 2021 Dec 28;S1201-9712(21)01255-8.
doi: 10.1016/j.ijid.2021.12.356. Online ahead of print.
Community seroprevalence and risk factors for SARS CoV-2 infection in different subpopulations in Vellore, India and its implications for future prevention
Divya Dayanand[SUP] 1 [/SUP], Indhuja Irudhayanathan[SUP] 1 [/SUP], Debasree Kundu[SUP] 1 [/SUP], Abi Manesh[SUP] 1 [/SUP], Vinod Abraham[SUP] 2 [/SUP], Kundavaram Pp Abhilash[SUP] 3 [/SUP], Binila Chacko[SUP] 4 [/SUP], Mahesh Moorthy[SUP] 5 [/SUP], Prasanna Samuel[SUP] 6 [/SUP], Pimnara Peerawaranun[SUP] 7 [/SUP], Mavuto Mukaka[SUP] 8 [/SUP], Jayaraj Joseph[SUP] 9 [/SUP], Mohanasankar Sivaprakasam[SUP] 9 [/SUP], George M Varghese[SUP] 10 [/SUP]
Affiliations
Abstract
Objectives: To inform public health policy decisions through assessment of IgG antibody seroprevalence in the population and the risk factors for SARS-CoV-2 infection.
Methods: We estimated the seroprevalence of IgG antibodies among different subpopulations at the end of the first and second waves of the pandemic. We also assessed various risk factors associated with the seropositivity including socio demography, IgG antibodies against endemic human coronavirus and vaccination status.
Results: Of the 2433 consented participants, the overall estimated seroprevalence at the end of first and second waves were 28.5% (95% CI:22.3%-33.7%) and 71.5% (95% CI:62.8%-80.5%), respectively. The accrual of IgG positivity was heterogeneous, with highest seroprevalence among the urban slum population(75.1%). Vaccine uptake was varied among the subpopulations, with low rates (<10%) among the rural and urban slums. The majority of seropositive individuals (75%) were asymptomatic. Residence in urban slums (OR 2.02; 95% CI:1.57-2.6; p<0.001), middle socioeconomic status (OR 1.77; 95% CI:1.17-2.67; p=0.007), presence of diabetes (OR 1.721; 95% CI:1.148-2.581; p=0.009), and hypertension (OR 1.75; 95% CI:1.16-2.64; p=0.008) were associated with seropositivity on multivariable analyses.
Conclusion: Although considerable population immunity has been reached with more than two-thirds seropositivity, improved vaccination strategies among unreached subpopulations and high-risk individuals are suggested for better preparedness in future.
Keywords: COVID; India; SARS CoV 2; Seroprevalence.
. 2021 Dec 28;S1201-9712(21)01255-8.
doi: 10.1016/j.ijid.2021.12.356. Online ahead of print.
Community seroprevalence and risk factors for SARS CoV-2 infection in different subpopulations in Vellore, India and its implications for future prevention
Divya Dayanand[SUP] 1 [/SUP], Indhuja Irudhayanathan[SUP] 1 [/SUP], Debasree Kundu[SUP] 1 [/SUP], Abi Manesh[SUP] 1 [/SUP], Vinod Abraham[SUP] 2 [/SUP], Kundavaram Pp Abhilash[SUP] 3 [/SUP], Binila Chacko[SUP] 4 [/SUP], Mahesh Moorthy[SUP] 5 [/SUP], Prasanna Samuel[SUP] 6 [/SUP], Pimnara Peerawaranun[SUP] 7 [/SUP], Mavuto Mukaka[SUP] 8 [/SUP], Jayaraj Joseph[SUP] 9 [/SUP], Mohanasankar Sivaprakasam[SUP] 9 [/SUP], George M Varghese[SUP] 10 [/SUP]
Affiliations
- PMID: 34971822
- DOI: 10.1016/j.ijid.2021.12.356
Abstract
Objectives: To inform public health policy decisions through assessment of IgG antibody seroprevalence in the population and the risk factors for SARS-CoV-2 infection.
Methods: We estimated the seroprevalence of IgG antibodies among different subpopulations at the end of the first and second waves of the pandemic. We also assessed various risk factors associated with the seropositivity including socio demography, IgG antibodies against endemic human coronavirus and vaccination status.
Results: Of the 2433 consented participants, the overall estimated seroprevalence at the end of first and second waves were 28.5% (95% CI:22.3%-33.7%) and 71.5% (95% CI:62.8%-80.5%), respectively. The accrual of IgG positivity was heterogeneous, with highest seroprevalence among the urban slum population(75.1%). Vaccine uptake was varied among the subpopulations, with low rates (<10%) among the rural and urban slums. The majority of seropositive individuals (75%) were asymptomatic. Residence in urban slums (OR 2.02; 95% CI:1.57-2.6; p<0.001), middle socioeconomic status (OR 1.77; 95% CI:1.17-2.67; p=0.007), presence of diabetes (OR 1.721; 95% CI:1.148-2.581; p=0.009), and hypertension (OR 1.75; 95% CI:1.16-2.64; p=0.008) were associated with seropositivity on multivariable analyses.
Conclusion: Although considerable population immunity has been reached with more than two-thirds seropositivity, improved vaccination strategies among unreached subpopulations and high-risk individuals are suggested for better preparedness in future.
Keywords: COVID; India; SARS CoV 2; Seroprevalence.
