tetano
Editor, Senior Moderator
Int J Infect Dis. 2020 Apr 11. pii: S1201-9712(20)30229-0. doi: 10.1016/j.ijid.2020.04.013. [Epub ahead of print]
Clinical manifestations and risk factors for mortality of patients with severe influenza during the 2016-2018 season.
Liu WD[SUP]1[/SUP], Yeh CY[SUP]2[/SUP], Shih MC[SUP]3[/SUP], Sheng WH[SUP]4[/SUP].
Author information
Abstract
OBJECTIVES:
Influenza remains a crucial transmissible disease from community. We aim to identify risk factors associated with mortality among hospitalized patients with severe influenza.
METHODS:
We retrospectively reviewed medical records of adult patients with laboratory-confirmed severe influenza at a medical center between January 2016 and December 2018. The primary outcome was 30-day all-cause mortality.
RESULTS:
Totally 96 patients were enrolled, with 73 patients in the influenza A group and 23 in the influenza B group. Eighteen (18.8%) deaths occurred within 30 days of hospitalization, including 8 (11%) and 10 (43.5%) of each group. In multivariable Cox regression analysis, factors associated with mortality were underlying diseases of liver cirrhosis (adjusted hazard ratio [AHR], 3.94; 95% CI, 1.07-14.45) and rheumatologic diseases (AHR, 7.45; 95% CI, 2.34-23.69) and the diagnosis of influenza B (AHR, 4.33; 95% CI, 1.68-11.13).
CONCLUSIONS:
Clinician should early identify high-risk population and warning signs of severe influenza. Our results support the policy of quadrivalent influenza vaccination because influenza B could be associated with high mortality.
Copyright ? 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
KEYWORDS:
influenza A; influenza B; liver cirrhosis; risk factor; severe influenza
PMID:32289562DOI:10.1016/j.ijid.2020.04.013
Clinical manifestations and risk factors for mortality of patients with severe influenza during the 2016-2018 season.
Liu WD[SUP]1[/SUP], Yeh CY[SUP]2[/SUP], Shih MC[SUP]3[/SUP], Sheng WH[SUP]4[/SUP].
Author information
Abstract
OBJECTIVES:
Influenza remains a crucial transmissible disease from community. We aim to identify risk factors associated with mortality among hospitalized patients with severe influenza.
METHODS:
We retrospectively reviewed medical records of adult patients with laboratory-confirmed severe influenza at a medical center between January 2016 and December 2018. The primary outcome was 30-day all-cause mortality.
RESULTS:
Totally 96 patients were enrolled, with 73 patients in the influenza A group and 23 in the influenza B group. Eighteen (18.8%) deaths occurred within 30 days of hospitalization, including 8 (11%) and 10 (43.5%) of each group. In multivariable Cox regression analysis, factors associated with mortality were underlying diseases of liver cirrhosis (adjusted hazard ratio [AHR], 3.94; 95% CI, 1.07-14.45) and rheumatologic diseases (AHR, 7.45; 95% CI, 2.34-23.69) and the diagnosis of influenza B (AHR, 4.33; 95% CI, 1.68-11.13).
CONCLUSIONS:
Clinician should early identify high-risk population and warning signs of severe influenza. Our results support the policy of quadrivalent influenza vaccination because influenza B could be associated with high mortality.
Copyright ? 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
KEYWORDS:
influenza A; influenza B; liver cirrhosis; risk factor; severe influenza
PMID:32289562DOI:10.1016/j.ijid.2020.04.013