tetano
Editor, Senior Moderator
Int J Infect Dis
. 2026 Feb 2:108459.
doi: 10.1016/j.ijid.2026.108459. Online ahead of print.
Associations of C-reactive protein-albumin-lymphocyte (CALLY) index with severity and prognosis in COVID-19 patients
Yong-Xia Guo[SUP] 1 [/SUP], Rui-Xiang Yang[SUP] 1 [/SUP], Shu-Shu Li[SUP] 1 [/SUP], Bo Liang[SUP] 1 [/SUP], Zi-Yong Chen[SUP] 1 [/SUP], Ying Zhang[SUP] 2 [/SUP], Lei Li[SUP] 2 [/SUP], Zhi-Yuan Tao[SUP] 2 [/SUP], Lin Fu[SUP] 3 [/SUP], Ya-Lin Jiang[SUP] 4 [/SUP]
Affiliations
Background: The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is associated with the status of inflammation, immunity, and nutrition in inflammatory diseases. The present research intends to investigate the relationships of the CALLY index with disease severity and clinical prognosis among patients with coronavirus disease 2019 (COVID-19).
Methods: The present study included 1049 COVID-19 subjects from two medical centers. Clinical information was gathered, and the CALLY index was calculated. The links of CALLY index with severity and prognosis were analyzed among COVID-19 cases.
Results: With disease severity scores increasing, the levels of CALLY on admission gradually decreased. Spearman correlative analyses showed that CALLY index was closely correlated with many clinical parameters. Linear and logistic regression analyses disclosed that the CALLY index was inversely related to disease severity scores. Simultaneously, the higher CALLY index on admission elevated the risks of mechanical ventilation, vasoactive agent, ICU admission, and death in COVID-19 patients during hospitalization. Logistic regression analysis further validated that the CALLY index was inversely linked to the poorly clinical outcomes. Moreover, the severity scores and the CALLY index on admission have similar predictive capacity for the poor prognosis in COVID-19 patients.
Conclusions: The CALLY index displays a negative relationship with disease severity and poor prognosis, indicating it can be served as a disease severity indicator and a prognostic tool for COVID-19 patients.
Keywords: CALLY index; COVID-19; biomarker; prognosis; severity.
. 2026 Feb 2:108459.
doi: 10.1016/j.ijid.2026.108459. Online ahead of print.
Associations of C-reactive protein-albumin-lymphocyte (CALLY) index with severity and prognosis in COVID-19 patients
Yong-Xia Guo[SUP] 1 [/SUP], Rui-Xiang Yang[SUP] 1 [/SUP], Shu-Shu Li[SUP] 1 [/SUP], Bo Liang[SUP] 1 [/SUP], Zi-Yong Chen[SUP] 1 [/SUP], Ying Zhang[SUP] 2 [/SUP], Lei Li[SUP] 2 [/SUP], Zhi-Yuan Tao[SUP] 2 [/SUP], Lin Fu[SUP] 3 [/SUP], Ya-Lin Jiang[SUP] 4 [/SUP]
Affiliations
- PMID: 41638351
- DOI: 10.1016/j.ijid.2026.108459
Background: The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is associated with the status of inflammation, immunity, and nutrition in inflammatory diseases. The present research intends to investigate the relationships of the CALLY index with disease severity and clinical prognosis among patients with coronavirus disease 2019 (COVID-19).
Methods: The present study included 1049 COVID-19 subjects from two medical centers. Clinical information was gathered, and the CALLY index was calculated. The links of CALLY index with severity and prognosis were analyzed among COVID-19 cases.
Results: With disease severity scores increasing, the levels of CALLY on admission gradually decreased. Spearman correlative analyses showed that CALLY index was closely correlated with many clinical parameters. Linear and logistic regression analyses disclosed that the CALLY index was inversely related to disease severity scores. Simultaneously, the higher CALLY index on admission elevated the risks of mechanical ventilation, vasoactive agent, ICU admission, and death in COVID-19 patients during hospitalization. Logistic regression analysis further validated that the CALLY index was inversely linked to the poorly clinical outcomes. Moreover, the severity scores and the CALLY index on admission have similar predictive capacity for the poor prognosis in COVID-19 patients.
Conclusions: The CALLY index displays a negative relationship with disease severity and poor prognosis, indicating it can be served as a disease severity indicator and a prognostic tool for COVID-19 patients.
Keywords: CALLY index; COVID-19; biomarker; prognosis; severity.