tetano
Editor, Senior Moderator
Int J Immunopathol Pharmacol
. Jan-Dec 2021;35:20587384211031763.
doi: 10.1177/20587384211031763.
The effectiveness of Colchicine as an anti-inflammatory drug in the treatment of coronavirus disease 2019: Meta-analysis
Monireh Golpour[SUP] 1 [/SUP], Tahoora Mousavi[SUP] 2 [/SUP], Mina Alimohammadi[SUP] 3 [/SUP], Ali Mosayebian[SUP] 3 [/SUP], Mohammadreza Shiran[SUP] 4 [/SUP], Reza Alizadeh Navaei[SUP] 5 [/SUP], Alireza Rafiei[SUP] 3 [/SUP]
Affiliations
Abstract
A recently discovered coronavirus, SARS-CoV-2, caused a global respiratory disease pandemic called COVID-19. Many studies have shown the excessive activation of the innate immune response that leads to the adverse outcomes of COVID-19, and anti-inflammatory drugs are very useful in the treatment and management of this infection. The activities of Colchicine, one of the anti-inflammatory drugs, target several pathways related to excessive inflammation of COVID-19. This study aimed to evaluate the efficacy of Colchicine in the treatment of COVID-19 using a meta-analysis approach. Scopus, Pubmed, Google scholars, Web of Science, and Science direct were used to search all the randomized controlled trials, case-control, and cross-sectional studies that have evaluated the efficacy of Colchicine as a treatment for COVID-19 (up to 28 May 2021). The overall effect of Colchicine versus the control group was determined using a random-effects model meta-analysis where we compared changes (i.e. mean differences-Colchicine group vs Control group) between the two conditions in test scores indicative of hospitalization time (day) and mortality rate. The results illustrated Colchicine therapy is associated with a decreased mortality rate in COVID-19 patients and associated with a decrease in hospitalization time (day) in COVID-19 patients. Present preliminary data shows that Colchicine has a beneficial effect on coronavirus disease care in 2019. Therefore, Colchicine can be a good suggestion in the management of COVID-19.
Keywords: COVID-19; Colchicine; anti-inflammatory; hospitalization time; mortality rate.
. Jan-Dec 2021;35:20587384211031763.
doi: 10.1177/20587384211031763.
The effectiveness of Colchicine as an anti-inflammatory drug in the treatment of coronavirus disease 2019: Meta-analysis
Monireh Golpour[SUP] 1 [/SUP], Tahoora Mousavi[SUP] 2 [/SUP], Mina Alimohammadi[SUP] 3 [/SUP], Ali Mosayebian[SUP] 3 [/SUP], Mohammadreza Shiran[SUP] 4 [/SUP], Reza Alizadeh Navaei[SUP] 5 [/SUP], Alireza Rafiei[SUP] 3 [/SUP]
Affiliations
- PMID: 34250834
- DOI: 10.1177/20587384211031763
Abstract
A recently discovered coronavirus, SARS-CoV-2, caused a global respiratory disease pandemic called COVID-19. Many studies have shown the excessive activation of the innate immune response that leads to the adverse outcomes of COVID-19, and anti-inflammatory drugs are very useful in the treatment and management of this infection. The activities of Colchicine, one of the anti-inflammatory drugs, target several pathways related to excessive inflammation of COVID-19. This study aimed to evaluate the efficacy of Colchicine in the treatment of COVID-19 using a meta-analysis approach. Scopus, Pubmed, Google scholars, Web of Science, and Science direct were used to search all the randomized controlled trials, case-control, and cross-sectional studies that have evaluated the efficacy of Colchicine as a treatment for COVID-19 (up to 28 May 2021). The overall effect of Colchicine versus the control group was determined using a random-effects model meta-analysis where we compared changes (i.e. mean differences-Colchicine group vs Control group) between the two conditions in test scores indicative of hospitalization time (day) and mortality rate. The results illustrated Colchicine therapy is associated with a decreased mortality rate in COVID-19 patients and associated with a decrease in hospitalization time (day) in COVID-19 patients. Present preliminary data shows that Colchicine has a beneficial effect on coronavirus disease care in 2019. Therefore, Colchicine can be a good suggestion in the management of COVID-19.
Keywords: COVID-19; Colchicine; anti-inflammatory; hospitalization time; mortality rate.