tetano
Editor, Senior Moderator
Int J Gynaecol Obstet
. 2022 Jul 16.
doi: 10.1002/ijgo.14359. Online ahead of print.
Should pregnant women be screened for SARS-CoV-2 infection? A prospective multicenter cohort study
Enav Yefet[SUP] #[/SUP][SUP] 1 2 [/SUP], Manal Massalha[SUP] #[/SUP][SUP] 3 4 [/SUP], Adi Alter[SUP] 1 [/SUP], Amit Gal Harnik[SUP] 1 [/SUP], Sally Hosari Mahamed[SUP] 3 [/SUP], Lia Novick[SUP] 1 [/SUP], Malak Wattad[SUP] 3 [/SUP], Jawad Sakas[SUP] 1 [/SUP], Shira Baram[SUP] 3 [/SUP], Amir Weiss[SUP] 3 4 [/SUP], Rula Iskander[SUP] 3 [/SUP], Avi Peretz[SUP] 2 5 [/SUP], Orit Rozenberg[SUP] 6 [/SUP], Johnny S Younis[SUP] 1 2 [/SUP], Yuri Perlitz[SUP] 1 2 [/SUP], Zohar Nachum[SUP] 3 4 [/SUP]
Affiliations
Abstract
Objective: The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranges from asymptomatic to severe infection. We aimed to compare the prevalence of COVID-19 in asymptomatic pregnant vs. non-pregnant women in order to establish recommendations for a COVID-19 screening strategy.
Methods: A prospective multicenter cohort study was conducted. Asymptomatic pregnant or non-pregnant women after March 2020 (the time when COVID-19 was first detected in north Israel) were tested for SARS-CoV-2 using nasopharyngeal reverse-transcription polymerase chain reaction test, anti-nucleocapside-IgG and anti-spike-IgG. Diagnosis was made if at least one test was positive. Pregnant women were tested between 34-42 weeks, mostly at birth.
Results: Among the 297 participating women, 152 were pregnant and 145 were non-pregnant. The prevalence of asymptomatic COVID-19 was similar between the groups (4 (2.6%) and 8 (5.5%), respectively, p=0.2). All women with COVID-19 delivered at term, healthy appropriate-for-gestational-age babies without malformations.
Conclusions: The rate of asymptomatic COVID-19 in pregnant women is low and comparable to the rate among non-pregnant women. Pregnancy outcomes are favorable. Future screening programs should consider that 1 of 25 screened asymptomatic women will be positive.
Keywords: COVID-19; Pregnancy; SARS-CoV-2; screening.
. 2022 Jul 16.
doi: 10.1002/ijgo.14359. Online ahead of print.
Should pregnant women be screened for SARS-CoV-2 infection? A prospective multicenter cohort study
Enav Yefet[SUP] #[/SUP][SUP] 1 2 [/SUP], Manal Massalha[SUP] #[/SUP][SUP] 3 4 [/SUP], Adi Alter[SUP] 1 [/SUP], Amit Gal Harnik[SUP] 1 [/SUP], Sally Hosari Mahamed[SUP] 3 [/SUP], Lia Novick[SUP] 1 [/SUP], Malak Wattad[SUP] 3 [/SUP], Jawad Sakas[SUP] 1 [/SUP], Shira Baram[SUP] 3 [/SUP], Amir Weiss[SUP] 3 4 [/SUP], Rula Iskander[SUP] 3 [/SUP], Avi Peretz[SUP] 2 5 [/SUP], Orit Rozenberg[SUP] 6 [/SUP], Johnny S Younis[SUP] 1 2 [/SUP], Yuri Perlitz[SUP] 1 2 [/SUP], Zohar Nachum[SUP] 3 4 [/SUP]
Affiliations
- PMID: 35842225
- DOI: 10.1002/ijgo.14359
Abstract
Objective: The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranges from asymptomatic to severe infection. We aimed to compare the prevalence of COVID-19 in asymptomatic pregnant vs. non-pregnant women in order to establish recommendations for a COVID-19 screening strategy.
Methods: A prospective multicenter cohort study was conducted. Asymptomatic pregnant or non-pregnant women after March 2020 (the time when COVID-19 was first detected in north Israel) were tested for SARS-CoV-2 using nasopharyngeal reverse-transcription polymerase chain reaction test, anti-nucleocapside-IgG and anti-spike-IgG. Diagnosis was made if at least one test was positive. Pregnant women were tested between 34-42 weeks, mostly at birth.
Results: Among the 297 participating women, 152 were pregnant and 145 were non-pregnant. The prevalence of asymptomatic COVID-19 was similar between the groups (4 (2.6%) and 8 (5.5%), respectively, p=0.2). All women with COVID-19 delivered at term, healthy appropriate-for-gestational-age babies without malformations.
Conclusions: The rate of asymptomatic COVID-19 in pregnant women is low and comparable to the rate among non-pregnant women. Pregnancy outcomes are favorable. Future screening programs should consider that 1 of 25 screened asymptomatic women will be positive.
Keywords: COVID-19; Pregnancy; SARS-CoV-2; screening.