tetano
Editor, Senior Moderator
Int J Gen Med
. 2021 Jul 24;14:3899-3907.
doi: 10.2147/IJGM.S317380. eCollection 2021.
Predictive Value of Neutrophil/Lymphocyte Ratio (NLR) on Cardiovascular Events in Patients with COVID-19
Lili Zhan[SUP] #[/SUP][SUP] 1 [/SUP], Yang Liu[SUP] #[/SUP][SUP] 2 [/SUP], Yanxiang Cheng[SUP] 1 [/SUP], Weichun Guo[SUP] 2 [/SUP], Jing Yang[SUP] 3 [/SUP]
Affiliations
Abstract
Background: The research on the association between coronavirus disease 2019 (COVID-19) and cardiovascular disease (CVD) is still insufficient.
Aim: This study aimed to investigate the association between neutrophil/lymphocyte ratio (NLR) and risk of cardiovascular events in patients with COVID-19.
Methods: Our study included 159 patients with COVID-19 who were measured for NLR value within the first 24 hours of admission. They were followed up for 6 months after discharge and then the relationship between levels of NLR and risk of cardiovascular events was assessed.
Results: In all included patients with COVID-19, NLR values in patients with cardiovascular events [16.28 (4.95-45.18)] were significantly higher than patients without cardiovascular events [4.75 (2.60-7.47)]. A multivariate logistic regression model revealed that elevated NLR value [increased per SD, 2.41 (1.43-4.29), P<0.001; increased 1 of NLR, 2.05 (1.33-4.01), P=0.010] was significantly and independently associated with increased risk of CVD history on admission after adjustment of related confounding factors. Then, Cox regression analysis revealed that elevated NLR value had a significant association with increased risk of cardiovascular events [increased per SD, 2.36 (1.42-4.36), P<0.001; Increased 1 of NLR, 2.00 (1.30-3.97), P=0.014] after adjustments of these same confounding factors. Furthermore, the ROC curve suggested that NLR value (AUC=0.803, 95% CI=0.731-0.875, P<0.001, sensitivity 81.2%, and specificity 82.6%) has a good predictive value for cardiovascular events during follow-up.
Conclusion: High NLR value was clinically associated with elevated risk of cardiovascular events in patients with COVID-19, which might be a potential biomarker for predicting cardiovascular events in the current COVID-19 pandemic.
Keywords: COVID-19; biomarker; cardiovascular events; neutrophil/lymphocyte ratio; predictive value.
. 2021 Jul 24;14:3899-3907.
doi: 10.2147/IJGM.S317380. eCollection 2021.
Predictive Value of Neutrophil/Lymphocyte Ratio (NLR) on Cardiovascular Events in Patients with COVID-19
Lili Zhan[SUP] #[/SUP][SUP] 1 [/SUP], Yang Liu[SUP] #[/SUP][SUP] 2 [/SUP], Yanxiang Cheng[SUP] 1 [/SUP], Weichun Guo[SUP] 2 [/SUP], Jing Yang[SUP] 3 [/SUP]
Affiliations
- PMID: 34335053
- PMCID: PMC8318887
- DOI: 10.2147/IJGM.S317380
Abstract
Background: The research on the association between coronavirus disease 2019 (COVID-19) and cardiovascular disease (CVD) is still insufficient.
Aim: This study aimed to investigate the association between neutrophil/lymphocyte ratio (NLR) and risk of cardiovascular events in patients with COVID-19.
Methods: Our study included 159 patients with COVID-19 who were measured for NLR value within the first 24 hours of admission. They were followed up for 6 months after discharge and then the relationship between levels of NLR and risk of cardiovascular events was assessed.
Results: In all included patients with COVID-19, NLR values in patients with cardiovascular events [16.28 (4.95-45.18)] were significantly higher than patients without cardiovascular events [4.75 (2.60-7.47)]. A multivariate logistic regression model revealed that elevated NLR value [increased per SD, 2.41 (1.43-4.29), P<0.001; increased 1 of NLR, 2.05 (1.33-4.01), P=0.010] was significantly and independently associated with increased risk of CVD history on admission after adjustment of related confounding factors. Then, Cox regression analysis revealed that elevated NLR value had a significant association with increased risk of cardiovascular events [increased per SD, 2.36 (1.42-4.36), P<0.001; Increased 1 of NLR, 2.00 (1.30-3.97), P=0.014] after adjustments of these same confounding factors. Furthermore, the ROC curve suggested that NLR value (AUC=0.803, 95% CI=0.731-0.875, P<0.001, sensitivity 81.2%, and specificity 82.6%) has a good predictive value for cardiovascular events during follow-up.
Conclusion: High NLR value was clinically associated with elevated risk of cardiovascular events in patients with COVID-19, which might be a potential biomarker for predicting cardiovascular events in the current COVID-19 pandemic.
Keywords: COVID-19; biomarker; cardiovascular events; neutrophil/lymphocyte ratio; predictive value.