tetano
Editor, Senior Moderator
Int J Gen Med
. 2021 Sep 8;14:5431-5440.
doi: 10.2147/IJGM.S330580. eCollection 2021.
Factors Associated with Mortality Among Hospitalized Adults with COVID-19 Pneumonia at a Private Tertiary Hospital in Tanzania: A Retrospective Cohort Study
Nadeem Kassam[SUP] 1 [/SUP], Eric Aghan[SUP] 2 [/SUP], Omar Aziz[SUP] 1 [/SUP], Hanifa Mbithe[SUP] 1 [/SUP], Kamran Hameed[SUP] 1 [/SUP], Reena Shah[SUP] 3 [/SUP], Salim Surani[SUP] 4 [/SUP], James Orwa[SUP] 5 [/SUP], Samina Somji[SUP] 1 [/SUP]
Affiliations
Abstract
Background: The emergence of the novel coronavirus disease 2019 (COVID-19) has caused millions of deaths worldwide. There has been paucity of data for hospitalized African patients suffering from COVID-19. This study aimed to identify factors associated with in-hospital mortality in patients suffering from COVID-19 in Tanzania.
Methods: This was a single center, retrospective, observational cohort study in adult patients hospitalized with confirmed COVID-19 infection. Demographics, clinical pattern, laboratory and radiological investigations associated with increased odds of mortality were analyzed.
Results: Of the 157 patients, 107 (68.1%) patients survived and 50 (31.8%) died. Mortality was highest in patients suffering with severe (26%) and critical (68%) forms of the disease. The median age of the cohort was 52 years (IQR 42-61), majority of patients were male (86%) and of African origin (46%), who presented with fever (69%), cough (62%) and difficulty in breathing (43%). Factors that were associated with mortality among our cohort were advanced age (OR 1.07, 95% CI 1.03-1.11), being overweight and obese (OR 9.44, 95% CI 2.71-41.0), suffering with severe form of the disease (OR 4.77, 95% CI 1.18-25.0) and being admitted to the HDU and ICU (OR 6.68, 95% CI 2.06-24.6).
Conclusion: The overall in-hospital mortality was 31.8%. Older age, obesity, the severe form of the disease and admission to the ICU and HDU were major risk factors associated with in-hospital mortality.
Keywords: COVID-19; Tanzania; factors; hospital; mortality.
. 2021 Sep 8;14:5431-5440.
doi: 10.2147/IJGM.S330580. eCollection 2021.
Factors Associated with Mortality Among Hospitalized Adults with COVID-19 Pneumonia at a Private Tertiary Hospital in Tanzania: A Retrospective Cohort Study
Nadeem Kassam[SUP] 1 [/SUP], Eric Aghan[SUP] 2 [/SUP], Omar Aziz[SUP] 1 [/SUP], Hanifa Mbithe[SUP] 1 [/SUP], Kamran Hameed[SUP] 1 [/SUP], Reena Shah[SUP] 3 [/SUP], Salim Surani[SUP] 4 [/SUP], James Orwa[SUP] 5 [/SUP], Samina Somji[SUP] 1 [/SUP]
Affiliations
- PMID: 34526810
- PMCID: PMC8436253
- DOI: 10.2147/IJGM.S330580
Abstract
Background: The emergence of the novel coronavirus disease 2019 (COVID-19) has caused millions of deaths worldwide. There has been paucity of data for hospitalized African patients suffering from COVID-19. This study aimed to identify factors associated with in-hospital mortality in patients suffering from COVID-19 in Tanzania.
Methods: This was a single center, retrospective, observational cohort study in adult patients hospitalized with confirmed COVID-19 infection. Demographics, clinical pattern, laboratory and radiological investigations associated with increased odds of mortality were analyzed.
Results: Of the 157 patients, 107 (68.1%) patients survived and 50 (31.8%) died. Mortality was highest in patients suffering with severe (26%) and critical (68%) forms of the disease. The median age of the cohort was 52 years (IQR 42-61), majority of patients were male (86%) and of African origin (46%), who presented with fever (69%), cough (62%) and difficulty in breathing (43%). Factors that were associated with mortality among our cohort were advanced age (OR 1.07, 95% CI 1.03-1.11), being overweight and obese (OR 9.44, 95% CI 2.71-41.0), suffering with severe form of the disease (OR 4.77, 95% CI 1.18-25.0) and being admitted to the HDU and ICU (OR 6.68, 95% CI 2.06-24.6).
Conclusion: The overall in-hospital mortality was 31.8%. Older age, obesity, the severe form of the disease and admission to the ICU and HDU were major risk factors associated with in-hospital mortality.
Keywords: COVID-19; Tanzania; factors; hospital; mortality.