tetano
Editor, Senior Moderator
Int J Environ Res Public Health
. 2021 Jan 27;18(3):1129.
doi: 10.3390/ijerph18031129.
Influenza Vaccine Effectiveness and Waning Effect in Hospitalized Older Adults. Valencia Region, Spain, 2018/2019 Season
Ainara Mira-Iglesias[SUP] 1 [/SUP], F Xavier L?pez-Labrador[SUP] 1 2 [/SUP], Javier Garc?a-Rubio[SUP] 1 [/SUP], Beatriz Mengual-Chuli?[SUP] 1 [/SUP], Miguel Tortajada-Girb?s[SUP] 3 [/SUP], Joan Mollar-Maseres[SUP] 4 [/SUP], Mario Carballido-Fern?ndez[SUP] 5 6 [/SUP], Germ?n Schwarz-Chavarri[SUP] 7 [/SUP], Joan Puig-Barber?[SUP] 1 8 [/SUP], Javier D?ez-Domingo[SUP] 1 [/SUP]
Affiliations
Abstract
Influenza vaccination is annually recommended for specific populations at risk, such as older adults. We estimated the 2018/2019 influenza vaccine effectiveness (IVE) overall, by influenza subtype, type of vaccine, and by time elapsed since vaccination among subjects 65 years old or over in a multicenter prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and other Respiratory Viruses (VAHNSI, Spain). Information about potential confounders was obtained from clinical registries and/or by interviewing patients and vaccination details were only ascertained by registries. A test-negative design was performed in order to estimate IVE. As a result, IVE was estimated at 46% (95% confidence interval (CI): (16%, 66%)), 41% (95% CI: (-34%, 74%)), and 45% (95% CI: (7%, 67%)) against overall influenza, A(H1N1)pdm09 and A(H3N2), respectively. An intra-seasonal not relevant waning effect was detected. The IVE for the adjuvanted vaccine in ≥75 years old was 45% (2%, 69%) and for the non-adjuvanted vaccine in 65-74 years old was 59% (-16%, 86%). Thus, our data revealed moderate vaccine effectiveness against influenza A(H3N2) and not significant against A(H1N1)pdm09. Significant protection was conferred by the adjuvanted vaccine to patients ≥75 years old. Moreover, an intra-seasonal not relevant waning effect was detected, and a not significant IVE decreasing trend was observed over time.
Keywords: effectiveness; hospitalizations; influenza; surveillance; vaccine; waning.
. 2021 Jan 27;18(3):1129.
doi: 10.3390/ijerph18031129.
Influenza Vaccine Effectiveness and Waning Effect in Hospitalized Older Adults. Valencia Region, Spain, 2018/2019 Season
Ainara Mira-Iglesias[SUP] 1 [/SUP], F Xavier L?pez-Labrador[SUP] 1 2 [/SUP], Javier Garc?a-Rubio[SUP] 1 [/SUP], Beatriz Mengual-Chuli?[SUP] 1 [/SUP], Miguel Tortajada-Girb?s[SUP] 3 [/SUP], Joan Mollar-Maseres[SUP] 4 [/SUP], Mario Carballido-Fern?ndez[SUP] 5 6 [/SUP], Germ?n Schwarz-Chavarri[SUP] 7 [/SUP], Joan Puig-Barber?[SUP] 1 8 [/SUP], Javier D?ez-Domingo[SUP] 1 [/SUP]
Affiliations
- PMID: 33514058
- DOI: 10.3390/ijerph18031129
Abstract
Influenza vaccination is annually recommended for specific populations at risk, such as older adults. We estimated the 2018/2019 influenza vaccine effectiveness (IVE) overall, by influenza subtype, type of vaccine, and by time elapsed since vaccination among subjects 65 years old or over in a multicenter prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and other Respiratory Viruses (VAHNSI, Spain). Information about potential confounders was obtained from clinical registries and/or by interviewing patients and vaccination details were only ascertained by registries. A test-negative design was performed in order to estimate IVE. As a result, IVE was estimated at 46% (95% confidence interval (CI): (16%, 66%)), 41% (95% CI: (-34%, 74%)), and 45% (95% CI: (7%, 67%)) against overall influenza, A(H1N1)pdm09 and A(H3N2), respectively. An intra-seasonal not relevant waning effect was detected. The IVE for the adjuvanted vaccine in ≥75 years old was 45% (2%, 69%) and for the non-adjuvanted vaccine in 65-74 years old was 59% (-16%, 86%). Thus, our data revealed moderate vaccine effectiveness against influenza A(H3N2) and not significant against A(H1N1)pdm09. Significant protection was conferred by the adjuvanted vaccine to patients ≥75 years old. Moreover, an intra-seasonal not relevant waning effect was detected, and a not significant IVE decreasing trend was observed over time.
Keywords: effectiveness; hospitalizations; influenza; surveillance; vaccine; waning.