tetano
Editor, Senior Moderator
Int J Environ Res Public Health
. 2021 Oct 30;18(21):11451.
doi: 10.3390/ijerph182111451.
Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis
Cheng-Chieh Chen[SUP] 1 2 [/SUP], Shou-Cheng Lu[SUP] 3 [/SUP], Chyi-Huey Bai[SUP] 4 [/SUP], Pei-Yu Wang[SUP] 3 [/SUP], Kang-Yun Lee[SUP] 5 6 [/SUP], Yuan-Hung Wang[SUP] 1 7 [/SUP]
Affiliations
Abstract
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused the global pandemic of coronavirus disease 2019 (COVID-19). Rapid identification and isolation of infectious patients are critical methods to block COVID-19 transmission. Antigen tests can contribute to prompt identification of infectious individuals. This meta-analysis aims to evaluate the diagnostic accuracy of antigen tests for SARS-CoV-2. We conducted a literature search in PubMed, Embase, the Cochrane Library, and Biomed Central databases. Studies evaluating the diagnostic accuracy of antigen tests for SARS-CoV-2 in community participants were included. Only English-language articles were reviewed. We included eligible studies that provided available data to construct a 2 × 2 table on a per-patient basis. Overall sensitivity and specificity for antigen tests were generated using a bivariate random-effects model. Eighteen studies with 34,865 participants were retrieved. The meta-analysis for SARS-CoV-2 antigen tests generated a pooled sensitivity of 0.82 and a pooled specificity of 1.00. A subgroup analysis of ten studies that reported outcomes for 5629 symptomatic participants generated a pooled sensitivity of 0.87 and a pooled specificity of 1.00. Antigen tests might have higher sensitivity in detecting SARS-CoV-2 in symptomatic patients in the community and may be an effective tool to identify patients to be quarantined to prevent further SARS-CoV-2 transmission.
Keywords: COVID-19; SARS-CoV-2; antigen test; meta-analysis; sensitivity and specificity.
. 2021 Oct 30;18(21):11451.
doi: 10.3390/ijerph182111451.
Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis
Cheng-Chieh Chen[SUP] 1 2 [/SUP], Shou-Cheng Lu[SUP] 3 [/SUP], Chyi-Huey Bai[SUP] 4 [/SUP], Pei-Yu Wang[SUP] 3 [/SUP], Kang-Yun Lee[SUP] 5 6 [/SUP], Yuan-Hung Wang[SUP] 1 7 [/SUP]
Affiliations
- PMID: 34769968
- DOI: 10.3390/ijerph182111451
Abstract
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused the global pandemic of coronavirus disease 2019 (COVID-19). Rapid identification and isolation of infectious patients are critical methods to block COVID-19 transmission. Antigen tests can contribute to prompt identification of infectious individuals. This meta-analysis aims to evaluate the diagnostic accuracy of antigen tests for SARS-CoV-2. We conducted a literature search in PubMed, Embase, the Cochrane Library, and Biomed Central databases. Studies evaluating the diagnostic accuracy of antigen tests for SARS-CoV-2 in community participants were included. Only English-language articles were reviewed. We included eligible studies that provided available data to construct a 2 × 2 table on a per-patient basis. Overall sensitivity and specificity for antigen tests were generated using a bivariate random-effects model. Eighteen studies with 34,865 participants were retrieved. The meta-analysis for SARS-CoV-2 antigen tests generated a pooled sensitivity of 0.82 and a pooled specificity of 1.00. A subgroup analysis of ten studies that reported outcomes for 5629 symptomatic participants generated a pooled sensitivity of 0.87 and a pooled specificity of 1.00. Antigen tests might have higher sensitivity in detecting SARS-CoV-2 in symptomatic patients in the community and may be an effective tool to identify patients to be quarantined to prevent further SARS-CoV-2 transmission.
Keywords: COVID-19; SARS-CoV-2; antigen test; meta-analysis; sensitivity and specificity.