tetano
Editor, Senior Moderator
Int J Environ Res Public Health
. 2021 Mar 27;18(7):3491.
doi: 10.3390/ijerph18073491.
Vitamin D Levels Are Reduced at the Time of Hospital Admission in Sicilian SARS-CoV-2-Positive Patients
Agostino Gaudio[SUP] 1 [/SUP], Andrea Ruben Murabito[SUP] 2 [/SUP], Antonella Agodi[SUP] 3 [/SUP], Arturo Montineri[SUP] 2 [/SUP], Pietro Castellino[SUP] 1 [/SUP], D O CoV Research
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) pandemic poses a worldwide healthcare challenge that needs an efficient response. Unfortunately, to date there is no highly effective treatment, so a deep understanding of COVID-19 risk factors could be an important step in treating the disease. Vitamin D affects the immune system in many different ways, and other authors already found that COVID-19 patients have low levels of vitamin D. In our retrospective study, we evaluated the vitamin D status at the time of hospital admission in 50 COVID-19 patients in Sicily, which is the southernmost region of Italy, and compared them with 100 control subjects matched for age and sex. Our data showed markedly low levels of vitamin D in patients with a positive polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but no association was found with inflammation markers or clinical severity. Vitamin D levels were reduced at the time of hospital admission in Sicilian SARS-CoV-2-positive patients, but it is not clear whether this condition has an impact on the clinical course of COVID-19.
Keywords: COVID-19; Sicily; immune system; vitamin D.
. 2021 Mar 27;18(7):3491.
doi: 10.3390/ijerph18073491.
Vitamin D Levels Are Reduced at the Time of Hospital Admission in Sicilian SARS-CoV-2-Positive Patients
Agostino Gaudio[SUP] 1 [/SUP], Andrea Ruben Murabito[SUP] 2 [/SUP], Antonella Agodi[SUP] 3 [/SUP], Arturo Montineri[SUP] 2 [/SUP], Pietro Castellino[SUP] 1 [/SUP], D O CoV Research
Affiliations
- PMID: 33801759
- DOI: 10.3390/ijerph18073491
Abstract
The coronavirus disease 2019 (COVID-19) pandemic poses a worldwide healthcare challenge that needs an efficient response. Unfortunately, to date there is no highly effective treatment, so a deep understanding of COVID-19 risk factors could be an important step in treating the disease. Vitamin D affects the immune system in many different ways, and other authors already found that COVID-19 patients have low levels of vitamin D. In our retrospective study, we evaluated the vitamin D status at the time of hospital admission in 50 COVID-19 patients in Sicily, which is the southernmost region of Italy, and compared them with 100 control subjects matched for age and sex. Our data showed markedly low levels of vitamin D in patients with a positive polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but no association was found with inflammation markers or clinical severity. Vitamin D levels were reduced at the time of hospital admission in Sicilian SARS-CoV-2-positive patients, but it is not clear whether this condition has an impact on the clinical course of COVID-19.
Keywords: COVID-19; Sicily; immune system; vitamin D.