tetano
Editor, Senior Moderator
Int J Endocrinol
. 2022 Apr 26;2022:9908450.
doi: 10.1155/2022/9908450. eCollection 2022.
Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia
Federica Tonon[SUP] 1 [/SUP], Stefano Di Bella[SUP] 1 2 [/SUP], Fabiola Giudici[SUP] 3 [/SUP], Verena Zerbato[SUP] 2 [/SUP], Ludovica Segat[SUP] 4 [/SUP], Raffaella Koncan[SUP] 1 [/SUP], Andrea Misin[SUP] 2 [/SUP], Barbara Toffoli[SUP] 1 [/SUP], Pierlanfranco D'Agaro[SUP] 1 4 [/SUP], Roberto Luzzati[SUP] 1 2 [/SUP], Bruno Fabris[SUP] 1 5 [/SUP], Stella Bernardi[SUP] 1 5 [/SUP]
Affiliations
Abstract
Purpose: Obesity is a risk factor for severe coronavirus disease 2019 (COVID-19). Circulating adipokines have been associated with inflammatory burden and amplified or dysregulated immune responses. This study aimed to evaluate the discriminatory ability of adipokines to identify COVID-19 pneumonia and to assess disease severity.
Methods: We conducted an observational case-control study, with a prospective design, and recruited patients with diagnosis of COVID-19 pneumonia (n = 48) and healthy controls (n = 36), who were matched by age, sex, and BMI. Leptin, adiponectin, IL-6, and TNF-α were measured by ELISA.
Results: Patients with COVID-19 pneumonia had higher levels of leptin, lower adiponectin/leptin (Adpn/Lep) ratio, and higher expression of IL-6. Leptin had an acceptable discriminatory accuracy for COVID-19 pneumonia in patients with BMI >30 (AUC 0.74 [0.58, 0.90]) with a cutoff of 7852 pg/mL and it was associated with maximum respiratory support. By contrast, Adpn/Lep had an excellent discriminatory accuracy for COVID-19 pneumonia in patients with BMI <25 (AUC 0.9 [0.74, 1.06]) with a cutoff of 2.23.
Conclusion: Our data indicate that high Adpn/Lep (>2.23) in lean patients is consistent with a state of good health, which decreases in case of inflammatory states, ranging from adipose tissue dysfunction with low-grade inflammation to COVID-19 pneumonia.
. 2022 Apr 26;2022:9908450.
doi: 10.1155/2022/9908450. eCollection 2022.
Discriminatory Value of Adiponectin to Leptin Ratio for COVID-19 Pneumonia
Federica Tonon[SUP] 1 [/SUP], Stefano Di Bella[SUP] 1 2 [/SUP], Fabiola Giudici[SUP] 3 [/SUP], Verena Zerbato[SUP] 2 [/SUP], Ludovica Segat[SUP] 4 [/SUP], Raffaella Koncan[SUP] 1 [/SUP], Andrea Misin[SUP] 2 [/SUP], Barbara Toffoli[SUP] 1 [/SUP], Pierlanfranco D'Agaro[SUP] 1 4 [/SUP], Roberto Luzzati[SUP] 1 2 [/SUP], Bruno Fabris[SUP] 1 5 [/SUP], Stella Bernardi[SUP] 1 5 [/SUP]
Affiliations
- PMID: 35529082
- PMCID: PMC9072020
- DOI: 10.1155/2022/9908450
Abstract
Purpose: Obesity is a risk factor for severe coronavirus disease 2019 (COVID-19). Circulating adipokines have been associated with inflammatory burden and amplified or dysregulated immune responses. This study aimed to evaluate the discriminatory ability of adipokines to identify COVID-19 pneumonia and to assess disease severity.
Methods: We conducted an observational case-control study, with a prospective design, and recruited patients with diagnosis of COVID-19 pneumonia (n = 48) and healthy controls (n = 36), who were matched by age, sex, and BMI. Leptin, adiponectin, IL-6, and TNF-α were measured by ELISA.
Results: Patients with COVID-19 pneumonia had higher levels of leptin, lower adiponectin/leptin (Adpn/Lep) ratio, and higher expression of IL-6. Leptin had an acceptable discriminatory accuracy for COVID-19 pneumonia in patients with BMI >30 (AUC 0.74 [0.58, 0.90]) with a cutoff of 7852 pg/mL and it was associated with maximum respiratory support. By contrast, Adpn/Lep had an excellent discriminatory accuracy for COVID-19 pneumonia in patients with BMI <25 (AUC 0.9 [0.74, 1.06]) with a cutoff of 2.23.
Conclusion: Our data indicate that high Adpn/Lep (>2.23) in lean patients is consistent with a state of good health, which decreases in case of inflammatory states, ranging from adipose tissue dysfunction with low-grade inflammation to COVID-19 pneumonia.