tetano
Editor, Senior Moderator
Int J Emerg Med
. 2021 Apr 21;14(1):24.
doi: 10.1186/s12245-021-00349-6.
Fulminant hepatic failure in a patient testing re-positive for SARS-CoV-2: a case report
Bader Aldossary[SUP] 1 [/SUP], Ali Hassan[SUP] 2 [/SUP], Mohamed Moussa[SUP] 1 [/SUP], Hind S Alsaif[SUP] 3 [/SUP], Dunya Alfaraj[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may not elicit lifelong protective immunity and reinfection could occur. Liver function impairment is a common manifestation of coronavirus disease 2019 (COVID-19). However, acute hepatic failure in the setting of COVID-19 is very rare.
Case presentation: We report the case of a 47-year-old woman who presented with acute abdominal pain and vomiting. Abdominal examination revealed a soft and lax abdomen with mild tenderness in the right upper quadrant. The patient recovered from COVID-19 2 months previously with negative results on reverse transcription-polymerase chain reaction (RT-PCR). Laboratory investigations revealed markedly elevated transaminases with normal results on viral hepatitis serology panel and undetectable blood paracetamol level. Prior to admission, the patient underwent RT-PCR for SARS-CoV-2, which revealed a positive result. The patient experienced rapid deterioration in the neurological status with a remarkable increase in the liver enzyme levels. Despite aggressive resuscitation, the patient suffered irreversible cardiac arrest and died.
Conclusion: Fulminant hepatic failure is a rare manifestation in patients with re-positive RT-PCR tests for SARS-CoV-2. Clinicians should maintain a high index of suspicion for hepatic injury with active monitoring of liver enzymes.
Keywords: COVID-19; Case reports; Liver failure; Re-infection; Re-positive test.
. 2021 Apr 21;14(1):24.
doi: 10.1186/s12245-021-00349-6.
Fulminant hepatic failure in a patient testing re-positive for SARS-CoV-2: a case report
Bader Aldossary[SUP] 1 [/SUP], Ali Hassan[SUP] 2 [/SUP], Mohamed Moussa[SUP] 1 [/SUP], Hind S Alsaif[SUP] 3 [/SUP], Dunya Alfaraj[SUP] 1 [/SUP]
Affiliations
- PMID: 33882839
- DOI: 10.1186/s12245-021-00349-6
Abstract
Background: Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may not elicit lifelong protective immunity and reinfection could occur. Liver function impairment is a common manifestation of coronavirus disease 2019 (COVID-19). However, acute hepatic failure in the setting of COVID-19 is very rare.
Case presentation: We report the case of a 47-year-old woman who presented with acute abdominal pain and vomiting. Abdominal examination revealed a soft and lax abdomen with mild tenderness in the right upper quadrant. The patient recovered from COVID-19 2 months previously with negative results on reverse transcription-polymerase chain reaction (RT-PCR). Laboratory investigations revealed markedly elevated transaminases with normal results on viral hepatitis serology panel and undetectable blood paracetamol level. Prior to admission, the patient underwent RT-PCR for SARS-CoV-2, which revealed a positive result. The patient experienced rapid deterioration in the neurological status with a remarkable increase in the liver enzyme levels. Despite aggressive resuscitation, the patient suffered irreversible cardiac arrest and died.
Conclusion: Fulminant hepatic failure is a rare manifestation in patients with re-positive RT-PCR tests for SARS-CoV-2. Clinicians should maintain a high index of suspicion for hepatic injury with active monitoring of liver enzymes.
Keywords: COVID-19; Case reports; Liver failure; Re-infection; Re-positive test.